Melioidosis and Burkholderia pseudomallei : progress in epidemiology, diagnosis, treatment and vaccination.


Journal

Current opinion in infectious diseases
ISSN: 1473-6527
Titre abrégé: Curr Opin Infect Dis
Pays: United States
ID NLM: 8809878

Informations de publication

Date de publication:
01 12 2022
Historique:
pubmed: 10 8 2022
medline: 10 11 2022
entrez: 9 8 2022
Statut: ppublish

Résumé

Melioidosis and its causative bacterium Burkholderia pseudomallei are being found in unexpected locations and bacterial genotyping is providing new insights into global spread and where and how individuals are being infected. This review summarizes recent studies covering the epidemiology, diagnosis, treatment, and prevention of melioidosis. Whole-genome sequencing of B. pseudomallei from patients and environmental sampling is informing the phylogeography of B. pseudomallei at regional, continental, and global levels, while also defining the epidemiology for individual cases. The situation in Africa remains the most unresolved, while the evolving story of B. pseudomallei in the Americas may establish that B. pseudomallei is endemic in parts of southern USA. Guidelines for diagnosis and treatment of melioidosis are well established, and published mortality has decreased from 50% or higher to 10% or lower in some countries but access to laboratory and therapeutic resources are not available or are extremely limited in many melioidosis-endemic regions. The enormous clinical diversity of melioidosis and the complexities of laboratory diagnosis and of treatment make it a sentinel disease for highlighting the continuing global disparities in access to and provision of healthcare.

Identifiants

pubmed: 35942848
doi: 10.1097/QCO.0000000000000869
pii: 00001432-202212000-00005
doi:

Types de publication

Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

517-523

Informations de copyright

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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Auteurs

Bart J Currie (BJ)

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University.
Infectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

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