LYTIC COCKTAIL ATTENUATES CATECHOLAMINE SURGE AFTER SEVERE BURNS BY BLOCKING HISTAMINE H1 RECEPTOR/PKA/CREB/TYROSINE HYDROXYLASE SIGNALING IN CHROMAFFIN CELLS.
Journal
Shock (Augusta, Ga.)
ISSN: 1540-0514
Titre abrégé: Shock
Pays: United States
ID NLM: 9421564
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
pubmed:
12
8
2022
medline:
30
9
2022
entrez:
11
8
2022
Statut:
ppublish
Résumé
Severe burns develop a catecholamine surge, inducing severe damage to the organism, raising the possibility of multisystem organ failure, and even death. The mechanisms of catecholamine surge have not been fully elucidated, and few strategies are generally acceptable to reduce catecholamine surge postburn. Thus, it is valuable to investigate the underlying mechanisms of catecholamine surge postburn to develop targeted interventions to attenuate it. We have found that the lytic cocktail alleviates the surge of catecholamine and organ injury after severe burn; however, the underlying mechanisms were still unclear. Moreover, the lytic cocktail has side effects, such as significant arterial hypotension and breathing depression, limiting its clinical application. This study aims to investigate the therapeutic mechanism of the lytic cocktail in regulating catecholamine levels postburn. We find that promethazine, a classic histamine H1 receptor blocker and a component of the lytic cocktail, can effectively reduce catecholamine surge and organ injury postburn. Our study confirms that blood histamine levels increase after severe burns. We find that histamine can amplify the catecholamine surge by elevating tyrosine hydroxylase expression and catecholamine synthesis in chromaffin cells through the histamine H1 receptor/Protein Kinase A /cAMP-response element binding protein signaling pathway. In summary, for the first time, we find that histamine plays a vital role in catecholamine surge postburn. We also confirm that the lytic cocktail effectively alleviates catecholamine surge and organ injury postburn through promethazine.
Identifiants
pubmed: 35953455
doi: 10.1097/SHK.0000000000001963
pii: 00024382-202208000-00009
doi:
Substances chimiques
Catecholamines
0
Receptors, Histamine H1
0
Histamine
820484N8I3
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Promethazine
FF28EJQ494
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-168Informations de copyright
Copyright © 2022 by the Shock Society.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Greenhalgh DG: Management of burns. N Engl J Med 380(24):2349–2359, 2019.
Kaddoura I, Abu-Sittah G, Ibrahim A, Karamanoukian R, Papazian N: Burn injury: review of pathophysiology and therapeutic modalities in major burns. Ann Burns Fire Disasters 30(2):95–102, 2017.
Zhang M, Yang P, Yu T, Harmsen MC, Gao M, Liu D, Shi Y, Liu Y, Zhang X: Lytic cocktail: an effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning. Heliyon 8:e09128, 2022.
Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R, Suman OE, Mlcak RP, Herndon DN: Long-term persistance of the pathophysiologic response to severe burn injury. PLoS One 6(7):e21245, 2011.
Bechmann N, Berger I, Bornstein SR, Steenblock C: Adrenal medulla development and medullary-cortical interactions. Mol Cell Endocrinol 528:111258, 2021.
Chakroborty D, Goswami S, Basu S, Sarkar C: Catecholamines in the regulation of angiogenesis in cutaneous wound healing. FASEB J 34(11):14093–14102, 2020.
Kopel J, Brower GL, Sorensen G, Griswold J: Application of beta-blockers in burn management. Proc (Baylor Univ Med Cent) 35(1):46–50, 2021.
Yang A, Liu B, Inoue T: Role of autonomic system imbalance in neurogenic pulmonary oedema. Eur J Neurosci 55(6):1645–1657, 2022.
Zhu Q, Gu L, Wang Y, Jia L, Zhao Z, Peng S, Lei L: The role of alpha-1 and alpha-2 adrenoceptors in restraint stress-induced liver injury in mice. PLoS One 9(3):e92125, 2014.
Abdullahi A, Wang V, Auger C, Patsouris D, Amini-Nik S, Jeschke MG: Catecholamines induce endoplasmic reticulum stress via both alpha and Beta receptors. Shock 53(4):476–484, 2020.
Lelou E, Corlu A, Nesseler N, Rauch C, Malledant Y, Seguin P, Aninat C: The Role of Catecholamines in Pathophysiological Liver Processes. Cell 11(6):1021, 2022.
Meunier-Cartal J, Souberbielle JC, Boureau F: Morphine and the “lytic cocktail” for terminally ill patients in a French general hospital: evidence for an inverse relationship. J Pain Symptom Manag 10(4):267–273, 1995.
Fang PY, Zhang Q, Liu Y: Review of sixty years of burn discipline in Shanghai Ruijin Hospital. Zhonghua Shao Shang Za Zhi 34(9):584–587, 2018.
Qiao L, Yuan K, Yang H, Dong H, Wang W, Xu W: Protective effect of lytic cocktail (inhibition of stress) on lung injury in severe burn rat. Zhonghua Shao Shang Za Zhi 24(4):251–253, 2008.
Williams FN, Herndon DN: Metabolic and endocrine considerations after burn injury. Clin Plast Surg 44(3):541–553, 2017.
Li L, Liu R, Peng C, Chen X, Li J: Pharmacogenomics for the efficacy and side effects of antihistamines. Exp Dermatol 31(7):993–1004, 2022.
Mazurkiewicz-Kwilecki IM, Peters DA: Effects of chronic treatment with histamine on catecholamine content and synthesis in rat brain, heart and adrenals. Biochem Pharmacol 22(24):3225–3235, 1973.
Smalley MC, Olivi J, Causa KA, Pathak M, Austin CL, Thompson SJ: Post-burn temporal dynamics of blood plasma histamine during the initial 6 days from injury. Int J Burns Trauma 10(3):68–75, 2020.
Schaefer TJ, Nunez LO: Burn Resuscitation and Management. In: StatPearls . Treasure Island (FL), 2021.
Wang J, Hu C, Wang J, Shen Y, Bao Q, He F, Wang H, Gong L, Liu Z, Hu F, et al.: Checkpoint blockade in combination with doxorubicin augments tumor cell apoptosis in osteosarcoma. J Immunother 42(9):321–330, 2019.
Gao M, Yu T, Liu D, Shi Y, Yang P, Zhang J, Wang J, Liu Y, Zhang X: Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1. Clin Sci (Lond) 135(2):347–365, 2021.
Huang Z, Meng C, Chen J, Chen Y, Chen Y, Zhou T, Yang C: Efficacy of fenofibrate for hepatic steatosis in rats after severe burn. Zhonghua Shao Shang Za Zhi 32(5):277–282, 2016.
Goodall MC, Alton H: Dopamine (3-hydroxytyramine) replacement and metabolism in sympathetic nerve and adrenal medullary depletions after prolonged thermal injury. J Clin Invest 48(9):1761–1767, 1969.
Potenzieri A, Riva B, Genazzani AA: Unexpected Ca 2+ -mobilization of oxaliplatin via H1 histamine receptors. Cell Calcium 86:102128, 2020.
Moniri NH, Booth RG: Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis. Neurosci Lett 407(3):249–253, 2006.
Juric DM, Mele T, Carman-Krzan M: Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes. Neuropharmacology 60(7–8):1309–1317, 2011.
Nagamoto-Combs K, Piech KM, Best JA, Sun B, Tank AW: Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive element binding protein-independent regulation. J Biol Chem 272(9):6051–6058, 1997.
Yang YJ, Lee HJ, Huang HS, Lee BK, Choi HS, Lim SC, Lee CK, Lee MK: Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. J Neurosci Res 87(8):1929–1937, 2009.
Edinoff AN, Kaplan LA, Khan S, Petersen M, Sauce E, Causey CD, Cornett EM, Imani F, Moradi Moghadam O, Kaye AM, et al.: Full opioid agonists and tramadol: pharmacological and clinical considerations. Anesth Pain Med 11(4):e119156, 2021.
Girgis RR, Zoghbi AW, Javitt DC, Lieberman JA: The past and future of novel, non-dopamine-2 receptor therapeutics for schizophrenia: a critical and comprehensive review. J Psychiatr Res 108:57–83, 2019.
Arantzamendi M, Belar A, Payne S, Rijpstra M, Preston N, Menten J, Van der Elst M, Radbruch L, Hasselaar J, Centeno C: Clinical aspects of palliative sedation in prospective studies. A systematic review. J Pain Symptom Manag 61(4):831–844.e10, 2021.
Papp A, Harma M, Harvima R, Lahtinen T, Uusaro A, Alhava E: Microdialysis for detection of dynamic changes in tissue histamine levels in experimental thermal injury. Burns 31(4):476–481, 2005.
Fukuda T, Ishii K, Nanmoku T, Isobe K, Kawakami Y, Takekoshi K: 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells. J Neuroendocrinol 19(8):621–631, 2007.
Marley PD, Robotis R: Activation of tyrosine hydroxylase by histamine in bovine chromaffin cells. J Auton Nerv Syst 70(1–2):1–9, 1998.
Kulp GA, Herndon DN, Lee JO, Suman OE, Jeschke MG: Extent and magnitude of catecholamine surge in pediatric burned patients. Shock 33(4):369–374, 2010.
Tekin I, Roskoski R Jr., Carkaci-Salli N, Vrana KE: Complex molecular regulation of tyrosine hydroxylase. J Neural Transm (Vienna) 121(12):1451–1481, 2014.