Adult Medulloblastoma: Updates on Current Management and Future Perspectives.
SHH inhibitors
SHH pathway
chemotherapy
medulloblastoma
neurosurgery
radiotherapy
sonic hedgehog (SHH)
sonidegib
targeted therapy
vismodegib
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Jul 2022
29 Jul 2022
Historique:
received:
12
06
2022
revised:
22
07
2022
accepted:
26
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Medulloblastoma (MB) is a malignant embryonal tumor of the posterior fossa belonging to the family of primitive neuro-ectodermic tumors (PNET). MB generally occurs in pediatric age, but in 14-30% of cases, it affects the adults, mostly below the age of 40, with an incidence of 0.6 per million per year, representing about 0.4-1% of tumors of the nervous system in adults. Unlike pediatric MB, robust prospective trials are scarce for the post-puberal population, due to the low incidence of MB in adolescent and young adults. Thus, current MB treatments for older patients are largely extrapolated from the pediatric experience, but the transferability and applicability of these paradigms to adults remain an open question. Adult MB is distinct from MB in children from a molecular and clinical perspective. Here, we review the management of adult MB, reporting the recent published literature focusing on the effectiveness of upfront chemotherapy, the development of targeted therapies, and the potential role of a reduced dose of radiotherapy in treating this disease.
Identifiants
pubmed: 35954372
pii: cancers14153708
doi: 10.3390/cancers14153708
pmc: PMC9367316
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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