Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents.
antibacterial
aromatic nucleophilic substitution
ciprofloxacin
piperidines
spirocyclic
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Jul 2022
29 Jul 2022
Historique:
received:
08
07
2022
revised:
23
07
2022
accepted:
26
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives of ciprofloxacin using commercially available 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and the literature protocol involving the preparation of boron chelate complex to facilitate nucleophilic aromatic substitution. All new fluoroquinolone derivatives were tested against two gram-positive as well as three gram-negative strains of bacteria. With the activity spectrum of the new derivatives being substantially narrower than that of ciprofloxacin, compounds were distinctly active against two of the five strains: gram-negative
Identifiants
pubmed: 35956812
pii: molecules27154864
doi: 10.3390/molecules27154864
pmc: PMC9370040
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Fluoroquinolones
0
Ciprofloxacin
5E8K9I0O4U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : 21-53-12001
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