Oleanane-Type Triterpene Conjugates with 1
fungicides
new pesticides
oleanolic acid
triazoles
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Aug 2022
02 Aug 2022
Historique:
received:
30
06
2022
revised:
28
07
2022
accepted:
28
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
The triazole pesticide is an organic nitrogen-containing heterocyclic compound with a 1,2,3-Triazole ring. In order to develop a potential glucosamine-6-phosphate synthase (GlmS) inhibitor bactericide, 18 triazole-derivative compounds were synthesized efficiently. In addition, these compounds have not been reported in the literature. The structure was confirmed by high-resolution mass spectrometry (HRMS), 1H NMR and 13C NMR. The potential use of the most promising derivatives has been investigated by testing their antifungal activity and enzyme inhibitory activity, revealing inhibitory activities in the low micromolar range. Among them, the antifungal effects of compounds
Identifiants
pubmed: 35956871
pii: molecules27154928
doi: 10.3390/molecules27154928
pmc: PMC9370531
pii:
doi:
Substances chimiques
Antifungal Agents
0
Triazoles
0
Triterpenes
0
oleanane
0
Oleanolic Acid
6SMK8R7TGJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Science Foundation of Beijing City
ID : No. 2194072
Organisme : Youth Foundation of Beijing University of Agriculture
ID : QNKJ202102
Organisme : the Seed Funding of Beijing Jinqiao Project
ID : No. JQ18029
Organisme : the General plan of Beijing Education Commission
ID : KM201710020003
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