Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.
Journal
Personality and mental health
ISSN: 1932-863X
Titre abrégé: Personal Ment Health
Pays: England
ID NLM: 101473502
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
26
07
2022
received:
22
02
2022
accepted:
29
07
2022
pubmed:
13
8
2022
medline:
22
2
2023
entrez:
12
8
2022
Statut:
ppublish
Résumé
Although multiple studies have shown the role genetics plays in personality disorders and in addictions, few have studied the genetic aspects of their comorbidity. Here, we carried out a cross-sectional study in a sample comprising 303 Caucasian polydrug-consuming patients. The presence of personality disorders was evaluated using the International Personality Disorder Examination, and genes related to dopamine, serotonin and monoamine oxidase (MAO) were genotyped. A significant relationship was observed between the bp 279 DRD5 variable number of tandem repeat (VNTR) polymorphism and paranoid personality disorder
Substances chimiques
Monoamine Oxidase
EC 1.4.3.4
DRD5 protein, human
0
Receptors, Dopamine D5
137750-35-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-86Informations de copyright
© 2022 The Authors Personality and Mental Health Published by John Wiley & Sons Ltd.
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