Dietary acrylamide and incident osteoporotic fractures: an 8-year prospective cohort study.
Acrylamide
Fracture
Osteoarthritis initiative
Osteoporosis
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
01
06
2022
accepted:
27
07
2022
pubmed:
14
8
2022
medline:
9
11
2022
entrez:
13
8
2022
Statut:
ppublish
Résumé
Acrylamide, a component of fried foods, has been associated with several negative health outcomes. However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few cross-sectional studies. To investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk/having knee osteoarthritis (OA), over 8 years of follow-up. A Cox's regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire and categorized in tertiles (T), whilst fractures' history was recorded using self-reported information. Altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1; < 3,313 μg), those with a higher acrylamide intake (T3; > 10,180 μg) reported a significantly higher risk of any fracture (HR = 1.37; 95% CI 1.12-1.68; p for trend = 0.009), forearm (HR = 1.73; 95% CI 1.09-2.77; p for trend = 0.04), spine (HR = 2.21; 95% CI 1.14-4.31; p for trend = 0.04), and hip fracture (HR = 4.09; 95% CI 1.29-12.96; p for trend = 0.046). Our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
Sections du résumé
BACKGROUND
BACKGROUND
Acrylamide, a component of fried foods, has been associated with several negative health outcomes. However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few cross-sectional studies.
AIMS
OBJECTIVE
To investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk/having knee osteoarthritis (OA), over 8 years of follow-up.
METHODS
METHODS
A Cox's regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire and categorized in tertiles (T), whilst fractures' history was recorded using self-reported information.
RESULTS
RESULTS
Altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1; < 3,313 μg), those with a higher acrylamide intake (T3; > 10,180 μg) reported a significantly higher risk of any fracture (HR = 1.37; 95% CI 1.12-1.68; p for trend = 0.009), forearm (HR = 1.73; 95% CI 1.09-2.77; p for trend = 0.04), spine (HR = 2.21; 95% CI 1.14-4.31; p for trend = 0.04), and hip fracture (HR = 4.09; 95% CI 1.29-12.96; p for trend = 0.046).
CONCLUSIONS
CONCLUSIONS
Our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
Identifiants
pubmed: 35962898
doi: 10.1007/s40520-022-02214-9
pii: 10.1007/s40520-022-02214-9
pmc: PMC9637630
doi:
Substances chimiques
Acrylamide
20R035KLCI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2441-2448Informations de copyright
© 2022. The Author(s).
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