Impaired myocellular Ca

Adrenergic Agents / metabolism Animals Calcium / metabolism Isoproterenol / pharmacology Mice Mice, Knockout Myocardial Contraction Myocytes, Cardiac / metabolism Phosphorylation Protein Phosphatase 2 / genetics Sarcoplasmic Reticulum / metabolism
LTCC PP2A-B56α myocellular Ca(2+) handling protein phosphorylation β-adrenergic function

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
09 2022
Historique:
received: 02 03 2022
revised: 25 07 2022
accepted: 26 07 2022
pubmed: 14 8 2022
medline: 30 9 2022
entrez: 13 8 2022
Statut: ppublish

Résumé

The activity of protein phosphatase 2A (PP2A) is determined by the expression and localization of the regulatory B-subunits. PP2A-B56α is the dominant isoform of the B'-family in the heart. Its role in regulating the cardiac response to β-adrenergic stimulation is not yet fully understood. We therefore generated mice deficient in B56α to test the functional cardiac effects in response to catecholamine administration versus corresponding WT mice. We found the decrease in basal PP2A activity in hearts of KO mice was accompanied by a counter-regulatory increase in the expression of B' subunits (β and γ) and higher phosphorylation of sarcoplasmic reticulum Ca

Identifiants

DOI: 10.1016/j.jbc.2022.102362 PMID: 35963431 PMC: PMC9478386
pubmed: 35963431
pii: S0021-9258(22)00805-5
doi: 10.1016/j.jbc.2022.102362
pmc: PMC9478386
pii:
doi:

Substances chimiques

Adrenergic Agents 0
Protein Phosphatase 2 EC 3.1.3.16
Isoproterenol L628TT009W
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102362

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Dennis Glaser (D)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Alexander Heinick (A)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Julius R Herting (JR)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Fabian Massing (F)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Frank U Müller (FU)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Paul Pauls (P)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Timofey S Rozhdestvensky (TS)

Department of Medicine, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Münster, Münster, Germany.

Jan S Schulte (JS)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Matthias D Seidl (MD)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Boris V Skryabin (BV)

Department of Medicine, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Münster, Münster, Germany.

Frank Stümpel (F)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Uwe Kirchhefer (U)

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany. Electronic address: kirchhef@uni-muenster.de.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Impaired myocellular Ca
questionsmedicales.fr › Eucaryotes › Animaux › Impaired myocellular Ca
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Impaired myocellular Ca
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Isoprénaline › Impaired myocellular Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Impaired myocellular Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Impaired myocellular Ca
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Impaired myocellular Ca
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Impaired myocellular Ca
questionsmedicales.fr › Métabolisme › Phosphorylation › Impaired myocellular Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein Phosphatase 2 › Impaired myocellular Ca
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Réticulum endoplasmique lisse › Réticulum sarcoplasmique › Impaired myocellular Ca