The role of dendritic cells in the immune niche of the peritoneum.

Dendritic Cells Immune Tolerance Peritoneum T-Lymphocytes
Dendritic cells Mesentery Milky spots Omentum Peritoneal cavity

Journal

International review of cell and molecular biology
ISSN: 1937-6448
Titre abrégé: Int Rev Cell Mol Biol
Pays: Netherlands
ID NLM: 101475846

Informations de publication

Date de publication:
2022
Historique:
entrez: 14 8 2022
pubmed: 15 8 2022
medline: 17 8 2022
Statut: ppublish

Résumé

Dendritic cells (DCs) are professional antigen presenting cells that play an important role in the induction of T cell responses. Different subsets (cDC1s, cDC2s, pDCs, and moDCs) were described based on the expression of different surface markers and functions. In the context of peritoneum, DCs are also a key population cell orchestrating immune responses against pathogens, malignant cells and tissue-damage. Furthermore, they play an important role in the promotion of an anti-inflammatory microenvironment, which is necessary to maintain tolerance and adipocyte homeostasis. The aim of this review is to summarize the current knowledge of the functional and phenotypic features of peritoneal DCs and shed some light on the importance of these cells within this unique cavity and its associated components: the omentum, the mesentery and gut-associated lymphoid tissue (GALT).

Identifiants

DOI: 10.1016/bs.ircmb.2022.04.012 PMID: 35964997
pubmed: 35964997
pii: S1937-6448(22)00057-0
doi: 10.1016/bs.ircmb.2022.04.012
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-14

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

David Repáraz (D)

Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBEREHD, Pamplona, Spain. Electronic address: dreparaz@alumni.unav.es.

Mirja Hommel (M)

Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.

Flor Navarro (F)

Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.

Diana Llopiz (D)

Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBEREHD, Pamplona, Spain. Electronic address: diallo@unav.es.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › The role of dendritic cells in the immune...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › The role of dendritic cells in the immune...
questionsmedicales.fr › Tissus › Membranes › Séreuse › Péritoine › The role of dendritic cells in the immune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › The role of dendritic cells in the immune...