Variation in TAS2R receptor genes explains differential bitterness of two common antibiotics.
T2Rs
bitter drugs
bitter taste receptors
chloramphenicol
ofloxacin
prop
propylthiouracil
taste psychophysics
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
06
2022
accepted:
29
06
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
For pharmaceuticals to deliver their full benefits with maximum efficacy, patients need to follow recommended dosing schedules, in terms of amount and frequency. Unfortunately, the aversive taste of many drugs, especially bitterness, can reduce patient compliance in oral liquid formulations. Given common genetic differences in bitter taste receptor genes (
Identifiants
pubmed: 35967977
doi: 10.3389/fgene.2022.960154
pii: 960154
pmc: PMC9366911
doi:
Types de publication
Journal Article
Langues
eng
Pagination
960154Informations de copyright
Copyright © 2022 Nolden, Hayes and Feeney.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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