Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy.
INPP4B
PI3Kα
PIKfyve
autophagy
lysosome
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
04 10 2022
04 10 2022
Historique:
revised:
19
07
2022
received:
14
12
2021
accepted:
21
07
2022
pubmed:
16
8
2022
medline:
6
10
2022
entrez:
15
8
2022
Statut:
ppublish
Résumé
Autophagy depends on the repopulation of lysosomes to degrade intracellular components and recycle nutrients. How cells co-ordinate lysosome repopulation during basal autophagy, which occurs constitutively under nutrient-rich conditions, is unknown. Here, we identify an endosome-dependent phosphoinositide pathway that links PI3Kα signaling to lysosome repopulation during basal autophagy. We show that PI3Kα-derived PI(3)P generated by INPP4B on late endosomes was required for basal but not starvation-induced autophagic degradation. PI(3)P signals were maintained as late endosomes matured into endolysosomes, and served as the substrate for the 5-kinase, PIKfyve, to generate PI(3,5)P
Identifiants
pubmed: 35968799
doi: 10.15252/embj.2021110398
pmc: PMC9531306
doi:
Substances chimiques
Phosphatidylinositol Phosphates
0
Protein Aggregates
0
Proteins
0
phosphatidylinositol 3-phosphate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e110398Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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