Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated with Reduced Susceptibility to β-Lactam Antibiotics in the United States, 2015-2021.

Agar Amoxicillin Ampicillin / pharmacology Anti-Bacterial Agents / pharmacology Lincosamides Macrolides Microbial Sensitivity Tests Monobactams Penicillin-Binding Proteins / genetics Peptidoglycan Peptidyl Transferases / genetics Phylogeny Streptococcus pneumoniae / genetics Streptococcus pyogenes / genetics United States beta-Lactam Resistance / genetics beta-Lactams / pharmacology
PBP2x catalytic site amino substituted β-lactams clinical susceptibility group A streptococcal lineages penicillin binding protein 2× transpeptidase domain

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
20 09 2022
Historique:
pubmed: 16 8 2022
medline: 24 9 2022
entrez: 15 8 2022
Statut: ppublish

Résumé

All known group A streptococci [GAS] are susceptible to β-lactam antibiotics. We recently identified an invasive GAS (iGAS) variant (

Identifiants

DOI: 10.1128/aac.00802-22 PMID: 35969070 PMC: PMC9487518
pubmed: 35969070
doi: 10.1128/aac.00802-22
pmc: PMC9487518
doi:

Substances chimiques

Anti-Bacterial Agents 0
Lincosamides 0
Macrolides 0
Monobactams 0
Penicillin-Binding Proteins 0
Peptidoglycan 0
beta-Lactams 0
Ampicillin 7C782967RD
Amoxicillin 804826J2HU
Agar 9002-18-0
Peptidyl Transferases EC 2.3.2.12

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0080222

Références

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Auteurs

Sopio Chochua (S)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.
ORCID: 0000-0001-8222-7353

Benjamin Metcalf (B)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Zhongya Li (Z)

ASRT Inc., Contractor to Respiratory Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Saundra Mathis (S)

ASRT Inc., Contractor to Respiratory Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Theresa Tran (T)

ASRT Inc., Contractor to Respiratory Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Joy Rivers (J)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Katherine E Fleming-Dutra (KE)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Yuan Li (Y)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Lesley McGee (L)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

Bernard Beall (B)

Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Galactanes › Agar-agar › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Benzylpénicilline › Ampicilline › Amoxicilline › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Benzylpénicilline › Ampicilline › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Glucides › Hétérosides › Lincosamides › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Monobactames › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines de liaison aux pénicillines › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › Polyosides bactériens › Peptidoglycane › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Aminoacyltransferases › Peptidyl transferases › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Résistance aux bêta-lactamines › Invasive Group A Streptococcal Penicillin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Invasive Group A Streptococcal Penicillin...