The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the T


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 08 2022
Historique:
entrez: 15 8 2022
pubmed: 16 8 2022
medline: 18 8 2022
Statut: ppublish

Résumé

Although glioblastoma multiforme (GBM) is not an invariably cold tumor, checkpoint inhibition has largely failed in GBM. In order to investigate T cell-intrinsic properties that contribute to the resistance of GBM to endogenous or therapeutically enhanced adaptive immune responses, we sorted CD4

Identifiants

pubmed: 35969754
doi: 10.1073/pnas.2206208119
pmc: PMC9407554
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2206208119

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Auteurs

Meike Mitsdoerffer (M)

Department of Neurology, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Lilian Aly (L)

Department of Neurology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Melanie Barz (M)

Department of Neurosurgery, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Thomas Engleitner (T)

Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Christopher Sie (C)

Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Claire Delbridge (C)

Department of Neuropathology, Institute of Pathology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Gildas Lepennetier (G)

Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Rupert Öllinger (R)

Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Monika Pfaller (M)

Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Benedikt Wiestler (B)

Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Neuroimaging group, TranslaTUM Cancer Center, Technical University of Munich, Munich, 81675 Germany.

Roland Rad (R)

Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Bernhard Meyer (B)

Department of Neurosurgery, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Benjamin Knier (B)

Department of Neurology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Friederike Schmidt-Graf (F)

Department of Neurology, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Jens Gempt (J)

Department of Neurosurgery, Technical University of Munich School of Medicine, 81675 Munich, Germany.

Thomas Korn (T)

Department of Neurology, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Institute for Experimental Neuroimmunology, Munich Cluster for Systems Neurology (SyNergy), Munich, 81377 Germany.

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Classifications MeSH