Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.

Alzheimer Disease / genetics Animals Apolipoprotein E2 / genetics Apolipoprotein E4 / genetics Astrocytes / metabolism Disease Models, Animal Glypicans / metabolism Humans Mice Mice, Transgenic Phosphorylation Tauopathies / metabolism tau Proteins / metabolism
APOE4 Alzheimer’s disease astrocytes glypican-4 tau pathology

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 08 2022
Historique:
entrez: 15 8 2022
pubmed: 16 8 2022
medline: 18 8 2022
Statut: ppublish

Résumé

Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including in Alzheimer's disease (AD). Apolipoprotein E4 (

Identifiants

DOI: 10.1073/pnas.2108870119 PMID: 35969759 PMC: PMC9407658
pubmed: 35969759
doi: 10.1073/pnas.2108870119
pmc: PMC9407658
doi:

Substances chimiques

Apolipoprotein E2 0
Apolipoprotein E4 0
Glypicans 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2108870119

Subventions

Organisme : NIA NIH HHS
ID : K01 AG062683
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063819
Pays : United States

Références

J Exp Med. 2016 Nov 14;213(12):2635-2654
pubmed: 27810929
JAMA Neurol. 2019 Aug 01;76(8):915-924
pubmed: 31157827
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4376-85
pubmed: 25261551
J Neurosci. 2011 Feb 2;31(5):1644-51
pubmed: 21289173
Nature. 2017 Sep 28;549(7673):523-527
pubmed: 28959956
Nat Med. 2019 Nov;25(11):1680-1683
pubmed: 31686034
Stem Cell Reports. 2017 Aug 8;9(2):600-614
pubmed: 28757165
Biomed Res Int. 2014;2014:516028
pubmed: 25157361
Annu Rev Neurosci. 2019 Jul 8;42:187-207
pubmed: 31283899
Nat Neurosci. 2016 Aug;19(8):1085-92
pubmed: 27322420
Nature. 2020 Apr;580(7803):381-385
pubmed: 32296178
Elife. 2014 Dec 17;3:
pubmed: 25517933
Nature. 2020 May;581(7806):71-76
pubmed: 32376954
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Neuron. 2018 Jun 27;98(6):1141-1154.e7
pubmed: 29861287
Nat Rev Neurol. 2016 Jan;12(1):15-27
pubmed: 26635213
Nat Neurosci. 2020 Dec;23(12):1555-1566
pubmed: 33199896
Nature. 2012 May 27;486(7403):410-4
pubmed: 22722203
Nat Neurosci. 2020 Dec;23(12):1567-1579
pubmed: 33169029
Nat Med. 2020 Jan;26(1):131-142
pubmed: 31932797
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
J Biol Chem. 2014 Jan 10;289(2):956-67
pubmed: 24235150
Science. 1988 Apr 29;240(4852):622-30
pubmed: 3283935
Cell. 2022 Jun 23;185(13):2213-2233.e25
pubmed: 35750033
Am J Manag Care. 2020 Aug;26(8 Suppl):S177-S183
pubmed: 32840331
Nat Med. 2020 Aug;26(8):1256-1263
pubmed: 32572268
Nat Rev Drug Discov. 2017 Dec;16(12):863-883
pubmed: 28983098
Alzheimers Dement (Amst). 2019 Sep 06;11:637-645
pubmed: 31517026
Nat Neurosci. 2019 Dec;22(12):2087-2097
pubmed: 31768052
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
J Biol Chem. 1981 Sep 10;256(17):9077-83
pubmed: 7263700
Glycobiology. 2010 May;20(5):533-41
pubmed: 20053627
Elife. 2019 Apr 30;8:
pubmed: 31038453
Neuron. 2020 Mar 4;105(5):855-866.e5
pubmed: 31924446
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245-9
pubmed: 3159021
Biol Psychiatry. 2015 Jan 1;77(1):43-51
pubmed: 24951455
Nat Commun. 2018 Apr 25;9(1):1655
pubmed: 29695808
Neuron. 2017 Oct 11;96(2):428-445.e13
pubmed: 29024665
Cold Spring Harb Perspect Biol. 2017 May 1;9(5):
pubmed: 27940517
Neuron. 2019 Mar 6;101(5):820-838
pubmed: 30844401
J Med Genet. 1994 Mar;31(3):197-200
pubmed: 8014966
JAMA Neurol. 2020 May 1;77(5):632-642
pubmed: 32091549
Nat Commun. 2017 Nov 13;8(1):1464
pubmed: 29133888
JAMA Neurol. 2018 Aug 1;75(8):989-998
pubmed: 29801024
Nat Med. 2018 Jan;24(1):29-38
pubmed: 29200205
Acta Neuropathol. 2018 Nov;136(5):699-708
pubmed: 30276465
JAMA Neurol. 2020 Apr 1;77(4):470-479
pubmed: 31860000
Nat Genet. 1994 Jun;7(2):180-4
pubmed: 7920638
Sci Transl Med. 2020 Jan 1;12(524):
pubmed: 31894103
Neurology. 1992 Mar;42(3 Pt 1):631-9
pubmed: 1549228
Brain. 2016 May;139(Pt 5):1551-67
pubmed: 26962052
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81
pubmed: 8446617
Am J Hum Genet. 1991 Jun;48(6):1034-50
pubmed: 2035524
Mol Psychiatry. 2019 Aug;24(8):1112-1134
pubmed: 30635637
J Neurosci. 2017 Nov 22;37(47):11406-11423
pubmed: 29054878
Neurology. 1993 Aug;43(8):1467-72
pubmed: 8350998
Brain Res. 1974 Sep 6;77(2):337-43
pubmed: 4604978
Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1305-15
pubmed: 27174096
Alzheimers Res Ther. 2018 Aug 7;10(1):77
pubmed: 30086796
Sci Adv. 2019 Jun 26;5(6):eaaw6404
pubmed: 31249873
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17513-8
pubmed: 17090684
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2018-22
pubmed: 19164761
Neuron. 2012 Feb 23;73(4):685-97
pubmed: 22365544
Nat Neurosci. 2020 Jun;23(6):701-706
pubmed: 32341542
Trends Endocrinol Metab. 2017 Apr;28(4):273-284
pubmed: 28057414
Sci Transl Med. 2016 Mar 30;8(332):332ra44
pubmed: 27030596

Auteurs

Sivaprakasam R Saroja (SR)

Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
ORCID: 0000-0002-0818-9966

Kirill Gorbachev (K)

Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Tcw Julia (T)

Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Alison M Goate (AM)

Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
ORCID: 0000-0002-0576-2472

Ana C Pereira (AC)

Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Eucaryotes › Animaux › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E2 › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Protéines liées au GPI › Glypicanes › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Métabolisme › Phosphorylation › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Tauopathies › Astrocyte-secreted glypican-4 drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Astrocyte-secreted glypican-4 drives...