Regional white matter hyperintensities in posterior cortical atrophy and logopenic progressive aphasia.
Fluid-attenuated inversion recovery
Logopenic progressive aphasia
Magnetic resonance imaging
Posterior cortical atrophy
White matter hyperintensity
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
13
12
2021
revised:
13
07
2022
accepted:
23
07
2022
pubmed:
16
8
2022
medline:
20
9
2022
entrez:
15
8
2022
Statut:
ppublish
Résumé
White matter hyperintensities (WMH) are markers of cerebral small vessel disease and are associated with higher risk of typical amnestic Alzheimer's disease (tAD). Little is known about the frequency and distribution of WMH in atypical variants of AD, including logopenic progressive aphasia (LPA) and posterior cortical atrophy (PCA). We investigated WMHs in 75 LPA, 39 PCA, and 50 tAD patients and associations with age, beta-amyloid PET burden, and cognition. PCA had greater subcortical WMHs in right occipital, parietal, and temporal lobes compared to LPA, and greater parieto-occipital subcortical and occipital periventricular WMHs than tAD. LPA had greater subcortical WMHs in left parietal lobe and deep white matter WMHs than PCA, and greater fronto-occipital subcortical and occipital periventricular WMHs than tAD. Total WMH increased with increasing age but was not related to beta-amyloid burden. Greater WMH was associated with visuoperceptual performance in LPA and PCA after correcting for atrophy. WMH topography differs across AD variants. Further work is needed to determine whether they reflect cerebrovascular disease or regionally specific neurodegenerative changes.
Identifiants
pubmed: 35970009
pii: S0197-4580(22)00162-2
doi: 10.1016/j.neurobiolaging.2022.07.008
pmc: PMC9886198
mid: NIHMS1864947
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-55Subventions
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050603
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC010367
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
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