Therapeutic efficacy of Nano-formulation of lactoperoxidase and lactoferrin via promoting immunomodulatory and apoptotic effects.
Antitumor
Breast cancer
DMBA
LPO and LF
Nano-formulation
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Nov 2022
01 Nov 2022
Historique:
received:
09
06
2022
revised:
27
07
2022
accepted:
10
08
2022
pubmed:
16
8
2022
medline:
15
10
2022
entrez:
15
8
2022
Statut:
ppublish
Résumé
This study identifies promising potential of a novel and safer nanocombination of bovine milk lactoperoxidase (LPO) and lactoferrin (LF) to target breast cancer in vitro and in adult female albino rat model. Favorable selective anticancer effects of the prepared nanocombination were observed, in a dose-dependent manner, against both MCF-7 and MDA cell lines, sparing normal HFB-4 cells. The administration of LPO + LFNPs markedly improved the induced-breast cancer disorders, prolonged survival and reduced the values of serum TNF-α, IL1β, CD4
Identifiants
pubmed: 35970364
pii: S0141-8130(22)01769-X
doi: 10.1016/j.ijbiomac.2022.08.067
pii:
doi:
Substances chimiques
Triglycerides
0
Tumor Necrosis Factor-alpha
0
Urea
8W8T17847W
Creatinine
AYI8EX34EU
Lactoperoxidase
EC 1.11.1.-
Superoxide Dismutase
EC 1.15.1.1
Lactoferrin
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-55Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.