A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA.

HIV-1 / genetics Nucleic Acid Conformation RNA, Small Nuclear / chemistry RNA-Binding Proteins / genetics Transcription Factors / metabolism

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
15 08 2022
Historique:
received: 09 02 2021
accepted: 19 07 2022
entrez: 15 8 2022
pubmed: 16 8 2022
medline: 18 8 2022
Statut: epublish

Résumé

Productive transcriptional elongation of many cellular and viral mRNAs requires transcriptional factors to extract pTEFb from the 7SK snRNP by modulating the association between HEXIM and 7SK snRNA. In HIV-1, Tat binds to 7SK by displacing HEXIM. However, without the structure of the 7SK-HEXIM complex, the constraints that must be overcome for displacement remain unknown. Furthermore, while structure details of the Tat

Identifiants

DOI: 10.1038/s42003-022-03734-w PMID: 35970937 PMC: PMC9378691
pubmed: 35970937
doi: 10.1038/s42003-022-03734-w
pii: 10.1038/s42003-022-03734-w
pmc: PMC9378691
doi:

Substances chimiques

RNA, Small Nuclear 0
RNA-Binding Proteins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

819

Subventions

Organisme : Howard Hughes Medical Institute
ID : 55108516
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM103297
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124169
Pays : United States
Organisme : NIH HHS
ID : S10 OD018483
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

Nucleic Acids Res. 2008 Apr;36(7):2219-29
pubmed: 18281698
Mol Biol Cell. 2010 Dec;21(23):4184-96
pubmed: 20881057
Biochimie. 2015 Oct;117:63-71
pubmed: 25863285
J Mol Biol. 2010 Jan 8;395(1):28-41
pubmed: 19883659
PLoS Pathog. 2010 Oct 14;6(10):e1001152
pubmed: 20976203
Mol Cell Biol. 2004 Jan;24(2):787-95
pubmed: 14701750
Biophys J. 2013 Aug 20;105(4):962-74
pubmed: 23972848
Nature. 2018 Aug;560(7720):607-612
pubmed: 30135578
Int J Breast Cancer. 2018 Oct 14;2018:6945129
pubmed: 30405916
Biochemistry. 2010 Apr 13;49(14):3083-91
pubmed: 20210365
J Biol Chem. 1995 May 26;270(21):12335-8
pubmed: 7759473
Cell. 1999 Apr 2;97(1):41-51
pubmed: 10199401
Nucleic Acids Res. 2007;35(6):2003-12
pubmed: 17341462
Science. 2017 Sep 1;357(6354):921-924
pubmed: 28775211
RNA. 2016 Dec;22(12):1844-1858
pubmed: 27852926
Nucleic Acids Res. 2005 Dec 23;33(22):7000-10
pubmed: 16377779
J Biol Chem. 2005 Aug 5;280(31):28819-26
pubmed: 15965233
Nucleic Acids Res. 2010 Nov;38(21):7749-63
pubmed: 20675720
J Biol Chem. 2014 Jul 25;289(30):21181-90
pubmed: 24917669
J Mol Biol. 1997 Oct 17;273(1):283-98
pubmed: 9367762
Wiley Interdiscip Rev RNA. 2020 Nov;11(6):e1598
pubmed: 32441456
Mol Cell Biol. 2004 Jun;24(12):5094-105
pubmed: 15169877
Science. 1992 Jul 3;257(5066):76-80
pubmed: 1621097
J Biol Chem. 2005 Apr 22;280(16):16360-7
pubmed: 15713662
Mol Cell Biol. 2006 Jan;26(2):630-42
pubmed: 16382153
Nat Commun. 2018 Oct 15;9(1):4266
pubmed: 30323330
J Biol Chem. 2004 Feb 6;279(6):4153-60
pubmed: 14627702
Nucleic Acids Res. 2020 Jan 10;48(1):373-389
pubmed: 31732748
Biochemistry. 1994 Mar 8;33(9):2708-15
pubmed: 8117736
PLoS One. 2010 Aug 23;5(8):e12335
pubmed: 20808803
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12721-12726
pubmed: 27791144
Nature. 2001 Nov 15;414(6861):322-5
pubmed: 11713533
J Biol Chem. 2021 Dec;297(6):101390
pubmed: 34767799
EMBO J. 2005 Dec 21;24(24):4291-303
pubmed: 16362050
Nucleic Acids Res. 2017 Apr 7;45(6):3568-3579
pubmed: 28082395
Tumour Biol. 2017 Feb;39(2):1010428317694304
pubmed: 28231737
Genes Dev. 1998 Feb 1;12(3):343-56
pubmed: 9450929
Science. 1995 Nov 17;270(5239):1200-3
pubmed: 7502045
Nat Med. 2002 Nov;8(11):1310-7
pubmed: 12368904
RNA. 2020 Sep;26(9):1184-1197
pubmed: 32430362
J Biol Chem. 2001 Nov 9;276(45):42601-9
pubmed: 11553615
J Virol. 2006 May;80(10):4781-91
pubmed: 16641271
Protein Expr Purif. 2002 Jun;25(1):8-15
pubmed: 12071693
Mol Cell. 2006 Jan 20;21(2):227-37
pubmed: 16427012
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11301-6
pubmed: 20534440
Nature. 2001 Nov 15;414(6861):317-22
pubmed: 11713532
J Biol Chem. 2001 Apr 13;276(15):12317-23
pubmed: 11145967
EMBO J. 2004 Jul 7;23(13):2608-19
pubmed: 15201869
Genes Dev. 1998 Mar 1;12(5):755-62
pubmed: 9499409
J Virol. 2010 Dec;84(24):12801-9
pubmed: 20926576
Mol Biol Evol. 2009 Dec;26(12):2821-30
pubmed: 19734296
J Biomol NMR. 2010 Jul;47(3):205-19
pubmed: 20549304
Methods Mol Biol. 2021;2323:49-66
pubmed: 34086273
Protein Sci. 2020 Jan;29(1):66-75
pubmed: 31576635
J Biol Chem. 2005 Apr 22;280(16):16368-76
pubmed: 15713661
J Am Chem Soc. 2020 Nov 25;142(47):19835-19839
pubmed: 33170672
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17349-54
pubmed: 17088550
Mol Biol Cell. 2020 Aug 1;31(17):1867-1878
pubmed: 32520633
J Biol Chem. 2005 Aug 26;280(34):30619-29
pubmed: 15994294
Mol Cell. 2010 May 14;38(3):439-51
pubmed: 20471949
Mol Cell. 2003 Oct;12(4):971-82
pubmed: 14580347
Nucleic Acids Res. 2017 Jun 20;45(11):6864-6880
pubmed: 28431135
Mol Cell Biol. 2003 Jul;23(14):4859-69
pubmed: 12832472
Nucleic Acids Res. 2016 Jul 8;44(W1):W424-9
pubmed: 27151198

Auteurs

Vincent V Pham (VV)

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.

Michael Gao (M)

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.

Jennifer L Meagher (JL)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.

Janet L Smith (JL)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
ORCID: 0000-0002-0664-9228

Victoria M D'Souza (VM)

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA. dsouza@mcb.harvard.edu.
ORCID: 0000-0002-5397-9481

Articles similaires

Expression interplay of genes coding for calcium-binding proteins and transcription factors during the osmotic phase provides insights on salt stress response mechanisms in bread wheat.

Diana Duarte-Delgado, Inci Vogt, Said Dadshani et al.
1.00
Triticum Transcription Factors Gene Expression Regulation, Plant Plant Proteins Salt Stress

Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors.

Yingyun Yang, Dahan Wen, Feng Lin et al.
1.00
Animals Humans Mice Neoplasms Tumor Microenvironment

Circular RNA landscape in extracellular vesicles from human biofluids.

Jingjing Zhao, Qiaojuan Li, Jia Hu et al.
1.00
Humans RNA, Circular Extracellular Vesicles Body Fluids Biomarkers

The SARS-CoV-2 ORF6 protein inhibits nuclear export of mRNA and spliceosomal U snRNA.

Ichiro Taniguchi
1.00
Animals Active Transport, Cell Nucleus RNA, Messenger Humans SARS-CoV-2

Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › A structure-based mechanism for displacement...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › A structure-based mechanism for displacement...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN nucléaire › A structure-based mechanism for displacement...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › A structure-based mechanism for displacement...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › A structure-based mechanism for displacement...