Anticancer potential of yohimbine in drug-resistant oral cancer KB-ChR-8-5 cells.

Adrenergic Antagonists / pharmacology Aphrodisiacs / pharmacology Apoptosis Cell Line, Tumor Humans Membrane Potential, Mitochondrial Mouth Neoplasms / drug therapy Reactive Oxygen Species / metabolism Yohimbine / pharmacology
Cytotoxicity Drug resistance ROS Yohimbine α2-adrenergic receptor antagonist

Journal

Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 07 06 2022
accepted: 05 08 2022
pubmed: 16 8 2022
medline: 30 9 2022
entrez: 15 8 2022
Statut: ppublish

Résumé

The demand for environmentally friendly and cost-effective plant-based products for the development of cancer therapeutics has been increasing. Yohimbine (α We estimated the anticancer efficacy of yohimbine using different assays, such as MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell cytotoxicity, cell morphology, cell apoptosis, reactive oxygen species (ROS) formation, and modulation in the mitochondrial membrane potential (MMP). Yohimbine showed a dose-dependent increase in cytotoxicity with a 50% inhibitory concentration (IC Overall, yohimbine showed a significant anticancer potential against drug-resistant oral cancer KB-ChR-8-5 cells. Our study suggests that besides being an aphrodisiac, yohimbine can be used as a drug repurposing agent. However, more research is required in different in vitro and in vivo models to confirm the feasibility of yohimbine in clinics.

Sections du résumé

BACKGROUND BACKGROUND
The demand for environmentally friendly and cost-effective plant-based products for the development of cancer therapeutics has been increasing. Yohimbine (α
METHODS METHODS
We estimated the anticancer efficacy of yohimbine using different assays, such as MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell cytotoxicity, cell morphology, cell apoptosis, reactive oxygen species (ROS) formation, and modulation in the mitochondrial membrane potential (MMP).
RESULTS RESULTS
Yohimbine showed a dose-dependent increase in cytotoxicity with a 50% inhibitory concentration (IC
CONCLUSION CONCLUSIONS
Overall, yohimbine showed a significant anticancer potential against drug-resistant oral cancer KB-ChR-8-5 cells. Our study suggests that besides being an aphrodisiac, yohimbine can be used as a drug repurposing agent. However, more research is required in different in vitro and in vivo models to confirm the feasibility of yohimbine in clinics.

Identifiants

DOI: 10.1007/s11033-022-07847-7 PMID: 35970968
pubmed: 35970968
doi: 10.1007/s11033-022-07847-7
pii: 10.1007/s11033-022-07847-7
doi:

Substances chimiques

Adrenergic Antagonists 0
Aphrodisiacs 0
Reactive Oxygen Species 0
Yohimbine 2Y49VWD90Q

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9565-9573

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature B.V.

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Auteurs

Nasimudeen R Jabir (NR)

Department of Biochemistry, Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, 613403, India.

Mohd Shahnawaz Khan (MS)

Department of Biochemistry, College of Sciences, King Saud University, Riyadh, 11451, Saudi Arabia. moskhan@ksu.edu.sa.

Nouf Omar Alafaleq (NO)

Department of Biochemistry, College of Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.

Huma Naz (H)

Department of Medicine, University of Missouri, Columbia, MO, 65201, USA.

Bakrudeen Ali Ahmed (BA)

Department of Biochemistry, Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, 613403, India. drbakru@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Anticancer potential of yohimbine in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Stimulants du système nerveux central › Aphrodisiaques › Anticancer potential of yohimbine in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Anticancer potential of yohimbine in...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Anticancer potential of yohimbine in...
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questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Potentiel de membrane mitochondriale › Anticancer potential of yohimbine in...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Tumeurs de la bouche › Anticancer potential of yohimbine in...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Anticancer potential of yohimbine in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indolizine › Indolizidines › Alcaloïdes indoliques › Alcaloïdes formés par condensation de sécologanine et de tryptamine › Yohimbine › Anticancer potential of yohimbine in...