UPEC Colonic-Virulence and Urovirulence Are Blunted by Proanthocyanidins-Rich Cranberry Extract Microbial Metabolites in a Gut Model and a 3D Tissue-Engineered Urothelium.
Humans
Anti-Bacterial Agents
/ pharmacology
Escherichia coli Infections
/ prevention & control
Escherichia coli Proteins
Plant Extracts
/ pharmacology
Proanthocyanidins
/ pharmacology
Urinary Tract Infections
/ prevention & control
Uropathogenic Escherichia coli
Urothelium
Vaccinium macrocarpon
Virulence
PAC
UPEC
cranberry
gut metabolome
urinary tract infections
urothelium
virulence genes
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
26 10 2022
26 10 2022
Historique:
pubmed:
17
8
2022
medline:
29
10
2022
entrez:
16
8
2022
Statut:
ppublish
Résumé
Uropathogenic Escherichia coli (UPEC) ecology-pathophysiology from the gut reservoir to its urothelium infection site is poorly understood, resulting in equivocal benefits in the use of cranberry as prophylaxis against urinary tract infections. To add further understanding from the previous findings on PAC antiadhesive properties against UPEC, we assessed in this study the effects of proanthocyanidins (PAC) rich cranberry extract microbial metabolites on UTI89 virulence and fitness in contrasting ecological UPEC's environments. For this purpose, we developed an original model combining a colonic fermentation system (SHIME) with a dialysis cassette device enclosing UPEC and a 3D tissue-engineered urothelium. Two healthy fecal donors inoculated the colons. Dialysis cassettes containing 7log
Identifiants
pubmed: 35972287
doi: 10.1128/spectrum.02432-21
pmc: PMC9603664
doi:
Substances chimiques
Anti-Bacterial Agents
0
Escherichia coli Proteins
0
Plant Extracts
0
Proanthocyanidins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243221Références
Nat Rev Microbiol. 2015 May;13(5):269-84
pubmed: 25853778
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Expert Opin Pharmacother. 2013 Apr;14(5):587-96
pubmed: 23480061
Biofactors. 2011 Mar-Apr;37(2):121-30
pubmed: 20806417
Am J Clin Nutr. 2016 Jun;103(6):1434-42
pubmed: 27251185
Nature. 2017 Jun 22;546(7659):528-532
pubmed: 28614296
Front Microbiol. 2019 May 31;10:1206
pubmed: 31214145
Planta Med. 2004 Dec;70(12):1103-14
pubmed: 15643541
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19695-19704
pubmed: 31501343
Food Funct. 2010 Dec;1(3):233-53
pubmed: 21776473
J Ethnopharmacol. 2020 Jul 15;257:112889
pubmed: 32311481
Food Chem. 2015 Sep 15;183:273-82
pubmed: 25863636
Cell Host Microbe. 2018 Aug 8;24(2):296-307.e7
pubmed: 30057174
Crit Rev Food Sci Nutr. 2009 Oct;49(9):741-81
pubmed: 20443158
Food Funct. 2019 Dec 11;10(12):7645-7652
pubmed: 31702761
J Tissue Eng Regen Med. 2017 May;11(5):1377-1389
pubmed: 26010652
Eur J Nutr. 2022 Apr;61(3):1299-1317
pubmed: 34750642
Front Microbiol. 2020 Sep 04;11:2094
pubmed: 33013764
Sci Rep. 2019 Dec 20;9(1):19590
pubmed: 31862919
Fitoterapia. 2017 Oct;122:67-75
pubmed: 28844930
Biomaterials. 2017 Nov;145:233-241
pubmed: 28888113
Dermatol Res Pract. 2016;2016:5397319
pubmed: 27051415
Front Microbiol. 2017 Apr 04;8:542
pubmed: 28421045
FEMS Microbiol Ecol. 2015 Jun;91(6):
pubmed: 25999470
Arch Toxicol. 2014 Oct;88(10):1803-53
pubmed: 25182418
Microbiol Spectr. 2015 Jun;3(3):
pubmed: 26185076
Front Cell Infect Microbiol. 2017 Jun 08;7:241
pubmed: 28642845
Molecules. 2020 Aug 01;25(15):
pubmed: 32752183
Appl Environ Microbiol. 2011 Oct;77(19):6852-7
pubmed: 21821749
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5977-82
pubmed: 16585510
Arch Biochem Biophys. 2016 Jun 1;599:31-41
pubmed: 26836705
Toxins (Basel). 2021 Jul 26;13(8):
pubmed: 34437391
Infect Immun. 2011 Mar;79(3):1225-35
pubmed: 21220482
Appl Microbiol Biotechnol. 2014 Aug;98(15):6805-15
pubmed: 24764016
Int J Med Microbiol. 2017 Dec;307(8):497-507
pubmed: 29031453
Nat Rev Urol. 2018 Dec;15(12):750-776
pubmed: 30361493
Microbiol Spectr. 2016 Oct;4(5):
pubmed: 27780014
PLoS One. 2018 Aug 23;13(8):e0202609
pubmed: 30138443
Adv Appl Microbiol. 2013;85:93-118
pubmed: 23942149
J Urol. 1997 Mar;157(3):1127-9
pubmed: 9072556
Pathogens. 2016 Jan 05;5(1):
pubmed: 26742079
FEMS Microbiol Ecol. 2018 Dec 1;94(12):
pubmed: 30239657
Nutrients. 2017 Mar 11;9(3):
pubmed: 28287476
PLoS Comput Biol. 2014 Apr 03;10(4):e1003531
pubmed: 24699258
BMC Biol. 2020 Oct 14;18(1):141
pubmed: 33054775
Antimicrob Resist Infect Control. 2019 Nov 20;8:181
pubmed: 31832181
Microorganisms. 2018 Nov 19;6(4):
pubmed: 30463258
Br J Nutr. 2017 Jun;117(12):1631-1644
pubmed: 28720150
Eur J Nutr. 2019 Jun;58(4):1529-1543
pubmed: 29616322