Venous thromboembolic and hemorrhagic events after meningioma surgery: A single-center retrospective cohort study of risk factors.

Humans Incidence Meningeal Neoplasms / complications Meningioma / surgery Postoperative Complications / epidemiology Retrospective Studies Venous Thromboembolism / epidemiology

Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2022
Historique:
received: 27 07 2021
accepted: 04 08 2022
entrez: 16 8 2022
pubmed: 17 8 2022
medline: 19 8 2022
Statut: epublish

Résumé

Microsurgical resection of meningiomas in a majority of cases leads to a favorable outcome. Therefore, severe postoperative adverse events are less acceptable. The main purpose of this study was to investigate the incidence of symptomatic venous thromboembolism (VTE) and hemorrhagic complications in patients after operative treatment of intracranial meningiomas and to identify the risk factors in this patient subgroup. Of 106 patients undergoing elective craniotomy for meningioma overall incidence of symptomatic VTE was noted in 5.7% (six patients). For the risk-factor analysis older age (57.20 ± 11.60 vs. 71.00 ± 0.90 years, p < 0.001), higher body mass index (27.60 ± 4.80 vs. 33.16 ± 0.60 kg/m2, p < 0.001), WHO grade II (3.00% vs. 33.33%, p = 0.02), lower intraoperative blood loss (466.00 ± 383.70 vs. 216.70 ± 68.30 mL, p < 0.001), bedridden status and neurologic deficit (0.00% vs. 33.33%, p = 0.003 and 38.00% vs. 100.00%, p = 0.004) were associated with greater VTE risk. No risk factors for hemorrhagic complications were identified on univariate analysis. In conclusion, the incidence of VTE in meningioma patients is not negligible. Identified risk factors should be taken into account in the decision-making process for chemoprophylaxis when the risk of bleeding decreases.

Identifiants

DOI: 10.1371/journal.pone.0273189 PMID: 35972947 PMC: PMC9380925
pubmed: 35972947
doi: 10.1371/journal.pone.0273189
pii: PONE-D-21-24338
pmc: PMC9380925
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0273189

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

Nebojsa Lasica (N)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Djula Djilvesi (D)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Vladimir Papic (V)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Mladen Karan (M)

Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.

Bojan Jelaca (B)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Jagos Golubovic (J)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Filip Pajicic (F)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Milica Medic-Stojanoska (M)

Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Serbia.

Petar Vulekovic (P)

Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Lukas Rasulic (L)

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia.
ORCID: 0000-0002-5674-0425

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Venous thromboembolic and hemorrhagic events...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Venous thromboembolic and hemorrhagic events...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs des méninges › Venous thromboembolic and hemorrhagic events...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs des méninges › Méningiome › Venous thromboembolic and hemorrhagic events...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Venous thromboembolic and hemorrhagic events...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Venous thromboembolic and hemorrhagic events...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thromboembolie › Thromboembolisme veineux › Venous thromboembolic and hemorrhagic events...