Chromosomal instability in adult-type diffuse gliomas.
Astrocytoma
CIN
Chromosomal instability
Chromothripsis
Copy number burden
Copy number variation
Glioblastoma
Glioma
Oligodendroglioma
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
17 08 2022
17 08 2022
Historique:
received:
12
07
2022
accepted:
04
08
2022
entrez:
17
8
2022
pubmed:
18
8
2022
medline:
20
8
2022
Statut:
epublish
Résumé
Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying mechanism of tumorigenesis and malignant progression, and has been documented in a wide variety of cancers, including colorectal carcinoma with mutations in genes such as APC. Recent reports have demonstrated that CIN, driven in part by mutations in genes maintaining overall genomic stability, is found in subsets of adult-type diffusely infiltrating gliomas of all histologic and molecular grades, with resulting elevated overall copy number burden, chromothripsis, and poor clinical outcome. Still, relatively few studies have examined the effect of this process, due in part to the difficulty of routinely measuring CIN clinically. Herein, we review the underlying mechanisms of CIN, the relationship between chromosomal instability and malignancy, the prognostic significance and treatment potential in various cancers, systemic disease, and more specifically, in diffusely infiltrating glioma subtypes. While still in the early stages of discovery compared to other solid tumor types in which CIN is a known driver of malignancy, the presence of CIN as an early factor in gliomas may in part explain the ability of these tumors to develop resistance to standard therapy, while also providing a potential molecular target for future therapies.
Identifiants
pubmed: 35978439
doi: 10.1186/s40478-022-01420-w
pii: 10.1186/s40478-022-01420-w
pmc: PMC9386991
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
115Subventions
Organisme : NINDS NIH HHS
ID : R01 NS106229
Pays : United States
Organisme : NIDA NIH HHS
ID : RF1 DA048810
Pays : United States
Informations de copyright
© 2022. The Author(s).
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