High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses.
Alzheimer’s disease
Brain metastases
COVID-19
Cerebrospinal fluid
Multiple sclerosis
Parkinson’s disease
Single-cell atlas
Single-cell transcriptomics
Journal
Genome medicine
ISSN: 1756-994X
Titre abrégé: Genome Med
Pays: England
ID NLM: 101475844
Informations de publication
Date de publication:
17 08 2022
17 08 2022
Historique:
received:
31
01
2022
accepted:
28
07
2022
entrez:
17
8
2022
pubmed:
18
8
2022
medline:
20
8
2022
Statut:
epublish
Résumé
The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant contact with the brain borders, thus permitting insights into the brain to diagnose and monitor diseases. Recently, the meninges, which are filled with CSF, were identified as a neuroimmunological interface, highlighting the potential of exploring central nervous system (CNS) immunity by studying CNS border compartments. Here, we summarize how single-cell transcriptomics of such border compartments advance our understanding of neurological diseases, the challenges that remain, and what opportunities novel multi-omic methods offer. Single-cell transcriptomics studies have detected cytotoxic CD4
Identifiants
pubmed: 35978442
doi: 10.1186/s13073-022-01097-9
pii: 10.1186/s13073-022-01097-9
pmc: PMC9385102
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
94Informations de copyright
© 2022. The Author(s).
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