Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases.
Nanoformulations
Neurodegeneration
Neuroprotection
Oxidative stress
Polyphenols
Journal
Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
04
02
2022
revised:
21
07
2022
accepted:
07
08
2022
pubmed:
20
8
2022
medline:
30
9
2022
entrez:
19
8
2022
Statut:
ppublish
Résumé
Neurodegenerative diseases (NDDs) are conditions that cause neuron structure and/or function to deteriorate over time. Genetic alterations may be responsible for several NDDs. However, a multitude of physiological systems can trigger neurodegeneration. Several NDDs, such as Huntington's, Parkinson's, and Alzheimer's, are assigned to oxidative stress (OS). Low concentrations of reactive oxygen and nitrogen species are crucial for maintaining normal brain activities, as their increasing concentrations can promote neural apoptosis. OS-mediated neurodegeneration has been linked to several factors, including notable dysfunction of mitochondria, excitotoxicity, and Ca
Identifiants
pubmed: 35985383
pii: S0045-6535(22)02513-9
doi: 10.1016/j.chemosphere.2022.136020
pii:
doi:
Substances chimiques
Polyphenols
0
Synthetic Drugs
0
Berberine
0I8Y3P32UF
Quercetin
9IKM0I5T1E
Genistein
DH2M523P0H
Curcumin
IT942ZTH98
Luteolin
KUX1ZNC9J2
Nitrogen
N762921K75
Resveratrol
Q369O8926L
Oxygen
S88TT14065
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
136020Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing for financial interests or personal relationships that could have appeared to influence the work reported in this paper.