Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.

Animals Citric Acid Cycle Humans Infertility, Male / genetics Isocitrate Dehydrogenase / genetics Isocitrates / metabolism Ketoglutaric Acids / metabolism Male Mice NAD / metabolism Retinal Degeneration Semen / metabolism Spermatogenesis
IDH3B TCA cycle male infertility metabolism retinal degeneration spermatogenesis spermatozoa spermiogenesis

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
09 2022
Historique:
received: 11 05 2022
revised: 08 08 2022
accepted: 10 08 2022
pubmed: 20 8 2022
medline: 30 9 2022
entrez: 19 8 2022
Statut: ppublish

Résumé

Isocitrate dehydrogenase 3 (IDH3) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate and concurrently converts NAD

Identifiants

DOI: 10.1016/j.jbc.2022.102387 PMID: 35985423 PMC: PMC9478456
pubmed: 35985423
pii: S0021-9258(22)00830-4
doi: 10.1016/j.jbc.2022.102387
pmc: PMC9478456
pii:
doi:

Substances chimiques

Isocitrates 0
Ketoglutaric Acids 0
NAD 0U46U6E8UK
isocitric acid 9RW6G5D4MQ
Isocitrate Dehydrogenase EC 1.1.1.41
isocitrate dehydrogenase 3, mouse EC 1.1.1.41

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102387

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103434
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031324
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY032462
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Siyan Zhu (S)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA; Department of Pharmaceutical and Pharmacological Science, West Virginia University, Morgantown, West Virginia, USA.

Jiancheng Huang (J)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA; Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.

Rong Xu (R)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.

Yekai Wang (Y)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.

Yiming Wan (Y)

Department of Biomedical Engineering Department, Stony Brook University, Stony Brook, New York, USA.

Rachel McNeel (R)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.

Edward Parker (E)

Department of Ophthalmology, University of Washington, Seattle, Washington, USA.

Douglas Kolson (D)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA.

Michelle Yam (M)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.

Bradley Webb (B)

Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.

Chen Zhao (C)

Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.

Jenna Sigado (J)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.

Jianhai Du (J)

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA. Electronic address: jianhai.du@hsc.wvu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Cycle citrique › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Infertilité masculine › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Isocitrate dehydrogenases › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Triacides carboxyliques › Citrates › Isocitrates › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Acides cétoglutariques › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Sperme › Isocitrate dehydrogenase 3b is required for...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Gamétogenèse › Spermatogenèse › Isocitrate dehydrogenase 3b is required for...