The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children.
Cardio-metabolic risk factors
Euthyroid obesity
Pediatric obesity
Thyroid function
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
20
03
2022
accepted:
09
08
2022
pubmed:
21
8
2022
medline:
25
1
2023
entrez:
20
8
2022
Statut:
ppublish
Résumé
The hormonal thyroid changes related to obesity, even when in the euthyroid state, may contribute to the unfavorable cardio-metabolic profile of obese patients. In this retrospective study, we aim to investigate the biochemical thyroid changes and the association between serum TSH, FT4, FT3 and cardio-metabolic risk factors in euthyroid obese youths. Four hundred ninety-one Caucasian euthyroid obese children and adolescents aged 9.93 ± 2.90 years were recruited. Each patient underwent clinical and auxological examination and laboratory workup including an OGTT and the measurement of thyroid function and lipid profile. Homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride to high-density lipoprotein cholesterol ratio, total cholesterol to HDL ratio, atherogenic index of plasma, insulinogenic index, area under the glucose and insulin curves were calculated. We found that TSH was positively correlated with BMI-SDS values and significantly associated with hypercholesterolemia and hyperinsulinemia; FT4 resulted negatively correlated with BMI-SDS; FT3 was positively correlated with BMI-SDS and the area under the curve of insulin and negatively correlated with HDL. FT3 and FT4 resulted significantly associated with severe obesity. In addition, children with high-normal TSH values showed higher triglyceride to high-density lipoprotein cholesterol ratio values than those with normal TSH levels. Our data showed that thyroid hormones could influence obesity, lipid and glycemic parameters in euthyroid youths. These findings could carry implications regarding optimal TSH levels in obese children and confirm the importance of evaluating the thyroid function as possible adjunctive cardio-metabolic risk factor related to obesity.
Identifiants
pubmed: 35986868
doi: 10.1007/s40618-022-01899-z
pii: 10.1007/s40618-022-01899-z
doi:
Substances chimiques
Insulin
0
Triglycerides
0
Cholesterol, HDL
0
Thyrotropin
9002-71-5
Thyroxine
Q51BO43MG4
Triiodothyronine
06LU7C9H1V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
285-295Informations de copyright
© 2022. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
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