Sex-specific analysis in Behçet's disease reveals higher genetic risk in male patients.

Humans Female Male Behcet Syndrome / diagnosis Genome-Wide Association Study Risk Factors HLA-C Antigens Genetic Testing
Behçet's disease GWAS Genetics HLA class I MHC Sex-bias

Journal

Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164

Informations de publication

Date de publication:
10 2022
Historique:
received: 23 06 2022
revised: 17 07 2022
accepted: 20 07 2022
pubmed: 21 8 2022
medline: 23 11 2022
entrez: 20 8 2022
Statut: ppublish

Résumé

Behçet's disease tends to be more severe in men than women. This study was undertaken to investigate sex-specific genetic effects in Behçet's disease. A total of 1762 male and 1216 female patients with Behçet's disease from six diverse populations were studied, with the majority of patients of Turkish origin. Genotyping was performed using an Infinium ImmunoArray-24 BeadChip, or extracted from available genotyping data. Following imputation and extensive quality control measures, genome-wide association analysis was performed comparing male to female patients in the Turkish cohort, followed by a meta-analysis of significant results in all six populations. In addition, a weighted genetic risk score for Behçet's disease was calculated and compared between male and female patients. Genetic association analysis comparing male to female patients with Behçet's disease from Turkey revealed an association with male sex in HLA-B/MICA within the HLA region with a GWAS level of significance (rs2848712, OR = 1.46, P = 1.22 × 10 Male patients with Behçet's disease are characterized by higher genetic risk compared to female patients. This genetic difference, primarily derived from our Turkish cohort, is largely explained by risk within the HLA region. These data suggest that genetic factors might contribute to differences in disease presentation between men and women with Behçet's disease.

Identifiants

DOI: 10.1016/j.jaut.2022.102882 PMID: 35987173 PMC: PMC10614427
pubmed: 35987173
pii: S0896-8411(22)00090-7
doi: 10.1016/j.jaut.2022.102882
pmc: PMC10614427
mid: NIHMS1938625
pii:
doi:

Substances chimiques

HLA-C Antigens 0

Types de publication

Meta-Analysis Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

102882

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR070148
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have declared that no conflict of interest exists.

Références

Cancer Res. 2006 Jan 1;66(1):563-70
pubmed: 16397273
Arthritis Rheum. 2009 Oct 15;61(10):1287-96
pubmed: 19790126
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Arthritis Rheumatol. 2021 Jul;73(7):1244-1252
pubmed: 33393726
Rheumatology (Oxford). 2012 May;51(5):887-900
pubmed: 22240504
Arthritis Res Ther. 2011 Mar 24;13(2):R49
pubmed: 21429233
Ann Rheum Dis. 2012 May;71(5):694-9
pubmed: 22110124
Front Med (Lausanne). 2021 Feb 12;8:625710
pubmed: 33644100
Curr Opin Rheumatol. 2018 May;30(3):238-242
pubmed: 29432223
Nat Genet. 2013 Feb;45(2):202-7
pubmed: 23291587
Ann Rheum Dis. 2015 Mar;74(3):618-24
pubmed: 24326010
Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8867-72
pubmed: 24821759
J Immunol. 2018 Feb 15;200(4):1496-1503
pubmed: 29311362
Ann Rheum Dis. 1984 Dec;43(6):783-9
pubmed: 6524980
J Ophthalmol. 2014;2014:820710
pubmed: 24864195
Rheumatology (Oxford). 2001 Jun;40(6):668-72
pubmed: 11426025
Am J Hum Genet. 2001 Jul;69(1):138-47
pubmed: 11404819
Arthritis Rheum. 2008 Dec;58(12):3951-9
pubmed: 19035493
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Arthritis Rheum. 2012 Dec;64(12):4104-13
pubmed: 23001997
PLoS One. 2015 Mar 23;10(3):e0119085
pubmed: 25799145
Clin Exp Rheumatol. 2010 Jul-Aug;28(4 Suppl 60):S50-7
pubmed: 20868571
Nat Genet. 2010 Aug;42(8):698-702
pubmed: 20622878
Evid Based Ment Health. 2019 Nov;22(4):153-160
pubmed: 31563865
Nat Genet. 2013 Mar;45(3):319-24
pubmed: 23396137
Nat Genet. 2010 Aug;42(8):703-6
pubmed: 20622879
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Arthritis Rheumatol. 2014 Jun;66(6):1648-58
pubmed: 24574333
Intern Emerg Med. 2019 Aug;14(5):653-660
pubmed: 30523495
Tissue Antigens. 1999 Sep;54(3):213-20
pubmed: 10519357
Genes Immun. 2015 Mar;16(2):176
pubmed: 25739881
Nat Genet. 2017 Mar;49(3):438-443
pubmed: 28166214
PLoS One. 2016 Aug 22;11(8):e0161305
pubmed: 27548383
Genet Epidemiol. 2007 May;31(4):306-15
pubmed: 17323372
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Clin Exp Rheumatol. 2007 Jul-Aug;25(4 Suppl 45):S46-51
pubmed: 17949551
Nat Commun. 2019 Mar 5;10(1):1052
pubmed: 30837455
Yonsei Med J. 1997 Dec;38(6):437-43
pubmed: 9509914
Yale J Biol Med. 2021 Dec 29;94(4):585-592
pubmed: 34970095
Rheumatology (Oxford). 2020 May 1;59(Suppl 3):iii101-iii107
pubmed: 32348523
Lancet. 1990 May 5;335(8697):1078-80
pubmed: 1970380
Nucleic Acids Res. 2013 Jan;41(Database issue):D56-63
pubmed: 23193274
FEBS Lett. 1999 Jun 18;453(1-2):187-90
pubmed: 10403400
Am J Hum Genet. 2013 Oct 3;93(4):687-96
pubmed: 24094745

Auteurs

Yun Gun Jo (YG)

Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.

Lourdes Ortiz-Fernández (L)

Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.

Patrick Coit (P)

Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.

Vuslat Yilmaz (V)

Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Sibel P Yentür (SP)

Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Fatma Alibaz-Oner (F)

Division of Rheumatology, Department of Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey.

Kenan Aksu (K)

Division of Rheumatology, Department of Internal Medicine, Ege University, School of Medicine, Izmir, Turkey.

Eren Erken (E)

Division of Rheumatology, Department of Internal Medicine, Çukurova University, School of Medicine, Adana, Turkey.

Nursen Düzgün (N)

Division of Rheumatology, Department of Internal Medicine, Ankara University, School of Medicine, Ankara, Turkey.

Gokhan Keser (G)

Division of Rheumatology, Department of Internal Medicine, Ege University, School of Medicine, Izmir, Turkey.

Ayse Cefle (A)

Division of Rheumatology, Department of Internal Medicine, Kocaeli University, School of Medicine, Kocaeli, Turkey.

Ayten Yazici (A)

Division of Rheumatology, Department of Internal Medicine, Kocaeli University, School of Medicine, Kocaeli, Turkey.

Andac Ergen (A)

Ophthalmology Clinic, Okmeydanı Research and Education Hospital, Istanbul, Turkey.

Erkan Alpsoy (E)

Department of Dermatology and Venereology, Akdeniz University, School of Medicine, Antalya, Turkey.

Carlo Salvarani (C)

Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia and Università di Modena e Reggio Emilia, Modena, Italy.

Bünyamin Kısacık (B)

Division of Rheumatology, Department of Internal Medicine, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey.

Ina Kötter (I)

Division of Rheumatology and Systemic Inflammatory Diseases, University Hospital Eppendorf, Hamburg, and Clinic for Rheumatology and Immunology, Bad Bramstedt, Germany.

Jörg Henes (J)

Center for Interdisciplinary Rheumatology, Immunology and Autoinflammatory Diseases (INDIRA) and Internal Medicine II (hematology, Oncology, Rheumatology and Immunology), University Hospital Tuebingen, Tuebingen, Germany.

Muhammet Çınar (M)

Division of Rheumatology, Department of Internal Medicine, University of Health Sciences Turkey, Gulhane Faculty of Medicine, Ankara, Turkey.

Arne Schaefer (A)

Department of Periodontology, Oral Medicine and Oral Surgery, Institute for Dental and Craniofacial Sciences, Charité-University Medicine Berlin, Berlin, Germany.

Rahime M Nohutcu (RM)

Department of Periodontology, Faculty of Dentistry, Hacettepe University Sihhiye, Ankara, Turkey.

Fujio Takeuchi (F)

School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan.

Shinji Harihara (S)

Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.

Toshikatsu Kaburaki (T)

Department of Ophthalmology, Jichi Medical University Saitama Medical Center, Japan.

Meriam Messedi (M)

Research Laboratory of Molecular Bases of Human Diseases, 12ES17, Faculty of Medicine of Sfax, University of Sfax, 3029 Sfax, Sfax, Tunisia.

Yeong-Wook Song (YW)

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, And College of Medicine, Medical Research Center, Seoul National University, Seoul, South Korea.

Timuçin Kaşifoğlu (T)

Division of Rheumatology, Department of Internal Medicine, Osmangazi University, School of Medicine, Eskisehir, Turkey.

Javier Martin (J)

Instituto de Parasitología y Biomedicina 'López-Neyra', IPBLN-CSIC, PTS Granada, Granada, Spain.

María Francisca González Escribano (MF)

Servicio de Inmunología, IBiS, Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevilla, Spain.

Güher Saruhan-Direskeneli (G)

Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Haner Direskeneli (H)

Division of Rheumatology, Department of Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey.

Amr H Sawalha (AH)

Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Lupus Center of Excellence, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: asawalha@pitt.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex-specific analysis in Behçet's disease...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses vasculaires › Maladie de Behçet › Sex-specific analysis in Behçet's disease...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Sex-specific analysis in Behçet's disease...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Sex-specific analysis in Behçet's disease...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-C › Sex-specific analysis in Behçet's disease...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Sex-specific analysis in Behçet's disease...