Susceptibility of OXA-48-producing Enterobacterales to imipenem/relebactam, meropenem/vaborbactam and ceftazidime/avibactam.

Anti-Bacterial Agents / pharmacology Azabicyclo Compounds / pharmacology Boronic Acids Carbapenems / pharmacology Ceftazidime / pharmacology Drug Combinations Imipenem / pharmacology Meropenem / pharmacology Microbial Sensitivity Tests Tazobactam beta-Lactamase Inhibitors / pharmacology beta-Lactamases / genetics
Carbapenemase Ceftolozane/tazobactam DBO β-Lactamase β-Lactamase inhibitor

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 23 05 2022
revised: 15 07 2022
accepted: 11 08 2022
pubmed: 22 8 2022
medline: 28 9 2022
entrez: 21 8 2022
Statut: ppublish

Résumé

Relebactam and vaborbactam are among the newest β-lactamase inhibitors marketed. They were originally designed to inhibit the Ambler class A carbapenemase KPC. In this study, susceptibility to imipenem/relebactam and meropenem/vaborbactam was determined against a collection of OXA-48-like-producing Enterobacterales (n = 407). The clonality and resistomes of the isolates were determined by whole-genome sequencing. Comparison was performed with other relevant antibiotics such as carbapenems alone, ceftazidime/avibactam and ceftolozane/tazobactam. Addition of relebactam and vaborbactam did not significantly modify the MIC

Identifiants

DOI: 10.1016/j.ijantimicag.2022.106660 PMID: 35988666
pubmed: 35988666
pii: S0924-8579(22)00181-9
doi: 10.1016/j.ijantimicag.2022.106660
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Azabicyclo Compounds 0
Boronic Acids 0
Carbapenems 0
Drug Combinations 0
beta-Lactamase Inhibitors 0
vaborbactam 1C75676F8V
Imipenem 71OTZ9ZE0A
avibactam 7352665165
Ceftazidime 9M416Z9QNR
beta-Lactamases EC 3.5.2.6
Meropenem FV9J3JU8B1
Tazobactam SE10G96M8W
relebactam Y1MYA2UHFL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106660

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Auteurs

Rémy A Bonnin (RA)

Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Paris-Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France.

Sandrine Bernabeu (S)

Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Paris-Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France; Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France.

Cécile Emeraud (C)

Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Paris-Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France; Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France.

Elodie Creton (E)

Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France.

Océane Vanparis (O)

Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France.

Thierry Naas (T)

Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Paris-Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France; Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France.

Agnès B Jousset (AB)

Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Paris-Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France; Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France.

Laurent Dortet (L)

Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Paris-Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriales, Le Kremlin-Bicêtre, France; Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France. Electronic address: laurent.dortet@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Composés hétérocycliques bicycliques › Composés azabicycliques › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Acides boroniques › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfaloridine › Ceftazidime › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Thiénamycine › Imipénem › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Thiénamycine › Méropénème › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Acide pénicillanique › Tazobactam › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Inhibiteurs des bêta-lactamases › Susceptibility of OXA-48-producing...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Susceptibility of OXA-48-producing...