Higher Cryopreserved CD34

Adult Humans Hepatic Veno-Occlusive Disease / epidemiology Ursodeoxycholic Acid / therapeutic use Retrospective Studies Cord Blood Stem Cell Transplantation / adverse effects Hematopoietic Stem Cell Transplantation / adverse effects Antigens, CD34 / therapeutic use Heparin / therapeutic use
Cord blood transplantation Heparin Sinusoidal obstruction syndrome Thrombomodulin Ursodeoxycholic acid Veno-occlusive disease

Journal

Transplantation and cellular therapy
ISSN: 2666-6367
Titre abrégé: Transplant Cell Ther
Pays: United States
ID NLM: 101774629

Informations de publication

Date de publication:
11 2022
Historique:
received: 27 06 2022
revised: 08 08 2022
accepted: 10 08 2022
pubmed: 23 8 2022
medline: 8 11 2022
entrez: 22 8 2022
Statut: ppublish

Résumé

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is one of the most serious complications to occur early after allogeneic hematopoietic cell transplantation (HCT). However, detailed data on VOD/SOS after cord blood transplantation (CBT) are not available. The objective of this retrospective study was to evaluate the incidence, risk factors, and clinical impact of VOD/SOS after single-unit unrelated CBT for adult patients at our institution. We retrospectively evaluated the incidence, risk factors, and outcomes of VOD/SOS after 390 single-unit unrelated CBTs performed in 332 adults under a prophylactic strategy of ursodeoxycholic acid (UDCA) and i.v. heparin at our institution between 1998 and 2021. VOD/SOS was observed in 24 of the 390 CBTs. The cumulative incidence of VOD/SOS was 5.9% at 30 days and 6.2% at 100 days after CBT. Multivariate analysis showed that cryopreserved CD34

Identifiants

DOI: 10.1016/j.jtct.2022.08.013 PMID: 35995391
pubmed: 35995391
pii: S2666-6367(22)01552-4
doi: 10.1016/j.jtct.2022.08.013
pii:
doi:

Substances chimiques

Ursodeoxycholic Acid 724L30Y2QR
Antigens, CD34 0
Heparin 9005-49-6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

779.e1-779.e9

Informations de copyright

Copyright © 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Auteurs

Seiko Kato (S)

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Takaaki Konuma (T)

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address: tkonuma@ims.u-tokyo.ac.jp.

Maki Monna-Oiwa (M)

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Masamichi Isobe (M)

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Satoshi Takahashi (S)

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Yasuhito Nannya (Y)

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Higher Cryopreserved CD34
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Higher Cryopreserved CD34
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladie veno-occlusive hépatique › Higher Cryopreserved CD34
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide désoxycholique › Acide ursodésoxycholique › Higher Cryopreserved CD34
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Higher Cryopreserved CD34
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches de sang du cordon › Higher Cryopreserved CD34
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Higher Cryopreserved CD34
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Antigènes CD34 › Higher Cryopreserved CD34
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Héparine › Higher Cryopreserved CD34