Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease.

Alzheimer Disease / diagnosis Amyloid beta-Peptides Biomarkers Cognitive Dysfunction / diagnostic imaging Humans Magnetic Resonance Imaging / methods Parietal Lobe / diagnostic imaging Temporal Lobe / diagnostic imaging

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
23 08 2022
Historique:
received: 20 08 2021
accepted: 16 03 2022
entrez: 22 8 2022
pubmed: 23 8 2022
medline: 25 8 2022
Statut: ppublish

Résumé

We assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy. We studied 499 participants aged 60-88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education. In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers. Novelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.

Sections du résumé

BACKGROUND AND OBJECTIVES
We assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy.
METHODS
We studied 499 participants aged 60-88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.
RESULTS
In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers.
DISCUSSION
Novelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.

Identifiants

DOI: 10.1212/WNL.0000000000200667 PMID: 35995589 PMC: PMC9484732
pubmed: 35995589
pii: WNL.0000000000200667
doi: 10.1212/WNL.0000000000200667
pmc: PMC9484732
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e775-e788

Informations de copyright

Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Ornella V Billette (OV)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Gabriel Ziegler (G)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Merita Aruci (M)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Hartmut Schütze (H)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Jasmin M Kizilirmak (JM)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Anni Richter (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0001-9681-6298

Slawek Altenstein (S)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Claudia Bartels (C)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Frederic Brosseron (F)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0003-3137-7516

Arturo Cardenas-Blanco (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0001-8683-8741

Philip Dahmen (P)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Peter Dechent (P)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Laura Dobisch (L)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Klaus Fliessbach (K)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Silka Dawn Freiesleben (SD)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Wenzel Glanz (W)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0002-5865-4176

Doreen Göerß (D)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

John Dylan Haynes (JD)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Michael T Heneka (MT)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Ingo Kilimann (I)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Okka Kimmich (O)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Luca Kleineidam (L)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Christoph Laske (C)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Andrea Lohse (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Ayda Rostamzadeh (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Coraline Metzger (C)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Matthias H Munk (MH)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Oliver Peters (O)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Lukas Preis (L)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Josef Priller (J)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Klaus Scheffler (K)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0001-6316-8773

Anja Schneider (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Annika Spottke (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Eike Jakob Spruth (EJ)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Alfredo Ramirez (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Sandra Röske (S)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Nina Roy (N)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Stefan Teipel (S)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Michael Wagner (M)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0003-2589-6440

Jens Wiltfang (J)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Steffen Wolfsgruber (S)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Renat Yakupov (R)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0002-3868-284X

Peter Zeidman (P)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Frank Jessen (F)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Björn H Schott (BH)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
ORCID: 0000-0002-8237-4481

Emrah Düzel (E)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.

Anne Maass (A)

From the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK. annemaass85@gmx.de.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe pariétal › Novelty-Related fMRI Responses of Precuneus...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe temporal › Novelty-Related fMRI Responses of Precuneus...