Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization.
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
07
2022
revised:
23
07
2022
accepted:
27
07
2022
entrez:
23
8
2022
pubmed:
24
8
2022
medline:
25
8
2022
Statut:
epublish
Résumé
Based on the latest genome-wide association study summary data, bidirectional two-sample Mendelian randomization (MR) was employed to detect the causal relationship and effect direction between TSH, fT4, and CRP. Furthermore, in view of obesity being an important risk factor of CVD, obesity trait waist-hip ratio (WHR) and body mass index (BMI) were treated as the research objects in MR analyses for exploring the causal effects of TSH and fT4 on them, respectively. Genetically increased CRP was associated with increased TSH ( TSH and fT4 were increased due to the higher genetically predicted CRP. WHR was decreased due to the higher genetically predicted TSH. These findings will provide reference for the prevention and treatment of inflammation and metabolic syndrome.
Identifiants
pubmed: 35996695
doi: 10.1155/2022/8954606
pmc: PMC9392607
doi:
Substances chimiques
Thyrotropin
9002-71-5
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8954606Informations de copyright
Copyright © 2022 Tingting Li et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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