Diphenhydramine: Time to Move on?

Humans Diphenhydramine / therapeutic use Histamine H1 Antagonists, Non-Sedating Histamine H1 Antagonists / therapeutic use Histamine Antagonists / therapeutic use Drug-Related Side Effects and Adverse Reactions / drug therapy
Antihistamines Cetirizine Diphenhydramine Fexofenadine

Journal

The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 24 05 2022
revised: 11 07 2022
accepted: 20 07 2022
pubmed: 24 8 2022
medline: 15 12 2022
entrez: 23 8 2022
Statut: ppublish

Résumé

Diphenhydramine is one of the most widely available, longest-used antihistamine medications but has many side effects including sedation and risk of toxicity in overdose including cardiac toxicity. It is frequently inappropriately used when newer, more favorable antihistamine medications are available. Second-generation antihistamines are also widely available and affordable, with many of the same desired effects as diphenhydramine and fewer, if any, of the undesirable side effects. Because of the negative side effects and wide availability of alternative antihistamine medications, it is definitively time to move on from diphenhydramine.

Identifiants

DOI: 10.1016/j.jaip.2022.07.018 PMID: 35999169
pubmed: 35999169
pii: S2213-2198(22)00746-2
doi: 10.1016/j.jaip.2022.07.018
pii:
doi:

Substances chimiques

Diphenhydramine 8GTS82S83M
Histamine H1 Antagonists, Non-Sedating 0
Histamine H1 Antagonists 0
Histamine Antagonists 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3124-3130

Informations de copyright

Copyright © 2022 American Academy of Allergy, Asthma & Immunology. All rights reserved.

Auteurs

Anna R Wolfson (AR)

Harvard Medical School, Boston, Mass; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass. Electronic address: awolfson@mgh.harvard.edu.

Dennis Wong (D)

Division of Clinical Immunology and Allergy, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Elissa M Abrams (EM)

University of Manitoba, Department of Pediatrics, Section of Allergy and Clinical Immunology, Winnipeg, MB, Canada; University of British Columbia, Department of Pediatrics, Division of Allergy and Immunology, Vancouver, BC, Canada.

Susan Waserman (S)

Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Gordon L Sussman (GL)

Division of Clinical Immunology and Allergy, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diphenhydramine: Time to Move on?
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Diphénhydramine › Diphenhydramine: Time to Move on?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents histaminiques › Antihistaminiques › Antihistaminiques des récepteurs H1 › Antihistaminiques H1 non sédatifs › Diphenhydramine: Time to Move on?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents histaminiques › Antihistaminiques › Antihistaminiques des récepteurs H1 › Diphenhydramine: Time to Move on?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents histaminiques › Antihistaminiques › Diphenhydramine: Time to Move on?
questionsmedicales.fr › Troubles dus à des produits chimiques › Effets secondaires indésirables des médicaments › Diphenhydramine: Time to Move on?