Warfarin pharmacogenomics in African populations: the importance of ethnicity-based algorithms.

Algorithms Anticoagulants / therapeutic use Cytochrome P-450 CYP2C9 Ethnicity / genetics Humans Pharmacogenetics Vitamin K Epoxide Reductases Warfarin / therapeutic use
Africa CYPC29 VKORC1 algorithm novel variants pharmacogenetics warfarin

Journal

Pharmacogenomics
ISSN: 1744-8042
Titre abrégé: Pharmacogenomics
Pays: England
ID NLM: 100897350

Informations de publication

Date de publication:
09 2022
Historique:
pubmed: 26 8 2022
medline: 21 9 2022
entrez: 25 8 2022
Statut: ppublish

Résumé

Tweetable abstract It is well accepted that pharmacogenomics (PGx) information from Asia and Europe should not be applied to Africa. More work is needed on different ethnic groups to generate population-specific algorithms that can be used effectively and safely.

Identifiants

DOI: 10.2217/pgs-2022-0067 PMID: 36004679
pubmed: 36004679
doi: 10.2217/pgs-2022-0067
doi:

Substances chimiques

Anticoagulants 0
Warfarin 5Q7ZVV76EI
Cytochrome P-450 CYP2C9 EC 1.14.13.-
Vitamin K Epoxide Reductases EC 1.17.4.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

753-757

Auteurs

Mwada Jallul (M)

Genetic Engineering Department, Libyan Biotechnology Research Centre, Tripoli, PO Box 30313, Libya.
ORCID: 0000-0001-6897-5785

Inas Alhudiri (I)

Genetic Engineering Department, Libyan Biotechnology Research Centre, Tripoli, PO Box 30313, Libya.
ORCID: 0000-0002-3371-0215

Laith Al-Eitan (L)

Department of Biotechnology & Genetic Engineering, Jordan University of Science & Technology, Irbid, 22110, Jordan.

Adam Elzagheid (A)

Genetic Engineering Department, Libyan Biotechnology Research Centre, Tripoli, PO Box 30313, Libya.
ORCID: 0000-0002-7086-5937

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Anticoagulants › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Limonène hydroxylases › Cytochrome P-450 CYP2C9 › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Caractéristiques de la population › Ethnies › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Professions de santé › Pharmacologie › Pharmacogénétique › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Vitamin K epoxide reductases › Warfarin pharmacogenomics in African...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › 4-Hydroxycoumarines › Warfarine › Warfarin pharmacogenomics in African...