GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
GJA1
Rab11
cell biology
cilia
developmental biology
mouse
xenopus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
25 08 2022
25 08 2022
Historique:
received:
13
06
2022
accepted:
11
08
2022
pubmed:
26
8
2022
medline:
9
9
2022
entrez:
25
8
2022
Statut:
epublish
Résumé
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit. A recent study showed that GJA1 is necessary for the maintenance of motile cilia; however, the molecular mechanism and function of GJA1 in ciliogenesis remain unknown. Here, we examined the functions of GJA1 during ciliogenesis in human retinal pigment epithelium-1 and
Identifiants
pubmed: 36004726
doi: 10.7554/eLife.81016
pii: 81016
pmc: PMC9448326
doi:
pii:
Substances chimiques
Connexin 43
0
GJA1 protein, human
0
Banques de données
Dryad
['10.5061/dryad.tht76hdxt']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Jang et al.
Déclaration de conflit d'intérêts
DJ, KK, YK, BK, KM, HL, CY, TK, TP No competing interests declared
Références
Pediatr Nephrol. 2011 Jul;26(7):1039-56
pubmed: 21210154
Dev Biol. 2009 Dec 15;336(2):183-91
pubmed: 19799895
Antioxid Redox Signal. 2009 Feb;11(2):283-95
pubmed: 18831677
Biochim Biophys Acta. 2013 Jan;1828(1):94-108
pubmed: 22613178
Cell. 2007 Jun 15;129(6):1201-13
pubmed: 17574030
Nat Cell Biol. 2015 Mar;17(3):228-240
pubmed: 25686250
Am J Hum Genet. 2018 Dec 6;103(6):984-994
pubmed: 30471717
Cell Physiol Biochem. 2010;25(2-3):279-92
pubmed: 20110689
Mol Membr Biol. 2002 Apr-Jun;19(2):121-36
pubmed: 12126230
J Cell Biol. 1987 Dec;105(6 Pt 1):2621-9
pubmed: 2826492
Curr Biol. 2001 Sep 4;11(17):1364-8
pubmed: 11553331
J Cell Biochem. 2010 Jun 1;110(3):589-97
pubmed: 20512920
J Cell Sci. 2019 Feb 15;132(5):
pubmed: 30665891
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6346-51
pubmed: 20308558
Am J Hum Genet. 2003 Feb;72(2):408-18
pubmed: 12457340
Nat Rev Mol Cell Biol. 2007 Nov;8(11):880-93
pubmed: 17955020
FEBS Lett. 2014 Apr 17;588(8):1339-48
pubmed: 24434540
J Biol Chem. 2008 Feb 8;283(6):2997-3001
pubmed: 18089569
Biochem Biophys Res Commun. 2005 Aug 12;333(4):1185-93
pubmed: 15979566
Physiol Rev. 2011 Oct;91(4):1393-445
pubmed: 22013215
Front Physiol. 2017 Nov 07;8:905
pubmed: 29163229
Trends Cell Biol. 2010 Feb;20(2):92-101
pubmed: 19944606
Methods Cell Biol. 1991;36:685-95
pubmed: 1811161
J Invest Dermatol. 2007 Nov;127(11):2516-24
pubmed: 17934503
Semin Cell Dev Biol. 2010 Apr;21(2):148-55
pubmed: 19591955
Eur J Clin Invest. 2011 Jan;41(1):103-16
pubmed: 20840374
Development. 2009 Sep;136(18):3185-93
pubmed: 19700622
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2759-64
pubmed: 21273506
Curr Biol. 2007 Jan 9;17(1):60-6
pubmed: 17208188
J Cell Sci. 2011 Feb 15;124(Pt 4):600-12
pubmed: 21266464
Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):192-201
pubmed: 28457858
J Mammary Gland Biol Neoplasia. 2003 Oct;8(4):463-73
pubmed: 14985641
Dev Dyn. 1992 Aug;194(4):261-81
pubmed: 1337483
Dev Cell. 2008 Aug;15(2):187-97
pubmed: 18694559
Biochim Biophys Acta. 2005 Dec 20;1719(1-2):6-23
pubmed: 16359940
Cilia. 2013 Jul 26;2(1):9
pubmed: 24053599
Cell Signal. 2006 May;18(5):592-600
pubmed: 16183253
Bioscience. 2014 Dec 1;64(12):1115-1125
pubmed: 26955067
Small GTPases. 2018 Mar 4;9(1-2):76-94
pubmed: 29072526
J Membr Biol. 1990 Jul;116(3):187-94
pubmed: 2167375
Trends Cell Biol. 2017 Feb;27(2):126-140
pubmed: 27634431
Biol Open. 2012 May 15;1(5):473-81
pubmed: 23213439
Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):48-64
pubmed: 28526583
Nat Cell Biol. 2016 Jun 28;18(7):711-7
pubmed: 27350441
Hum Mol Genet. 2008 Dec 1;17(23):3796-805
pubmed: 18772192
Cell Motil Cytoskeleton. 1986;6(1):25-34
pubmed: 2938744
Biol Chem. 2002 May;383(5):725-37
pubmed: 12108537
Biochim Biophys Acta. 2012 Aug;1818(8):1993-2001
pubmed: 22155212
Nucleic Acids Res. 2013 Jan;41(Database issue):D865-70
pubmed: 23125366
Cell Tissue Res. 2015 Jun;360(3):685-99
pubmed: 25547217
Cell. 2009 Apr 3;137(1):32-45
pubmed: 19345185
Annu Rev Biochem. 1996;65:475-502
pubmed: 8811187
Dev Dyn. 2009 Jun;238(6):1215-25
pubmed: 19208433
PLoS One. 2012;7(10):e48196
pubmed: 23110211
Dev Biol. 1998 Nov 1;203(1):90-105
pubmed: 9806775
Nat Commun. 2020 Apr 20;11(1):1860
pubmed: 32312952
Genomics. 1999 May 15;58(1):34-40
pubmed: 10331943
Cardiovasc Res. 2004 May 1;62(2):228-32
pubmed: 15094343
PLoS One. 2011;6(10):e26379
pubmed: 22022608
J Biol Chem. 2006 Mar 24;281(12):7994-8009
pubmed: 16407179
Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a002576
pubmed: 20066080