Analysis of sleep, daytime sleepiness, and autonomic function in multiple system atrophy and Parkinson disease: a prospective study.


Journal

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977

Informations de publication

Date de publication:
01 01 2023
Historique:
pmc-release: 01 01 2024
pubmed: 26 8 2022
medline: 4 1 2023
entrez: 25 8 2022
Statut: ppublish

Résumé

Sleep disorders, daytime sleepiness, and autonomic dysfunction are commonly reported among patients with multiple system atrophy and Parkinson disease (PD). We aimed to assess sleep and autonomic function in these patients to evaluate the relationships between sleep disorders, excessive daytime sleepiness, and autonomic function. Twenty patients with multiple system atrophy (n = 7) and PD (n = 13) underwent clinical assessment including questionnaires for autonomic function and sleep. Cardiovascular autonomic function tests and 2-night video-polysomnography were followed by administration of the Multiple Sleep Latency Test. Rapid eye movement sleep without atonia was quantified in the chin, flexor digitorum superficialis, tibial anterior, and sternocleidomastoid muscles. Rapid eye movement sleep behavior disorder was associated with orthostatic hypotension ( The relationship of autonomic dysfunction with rapid eye movement sleep without atonia in PD and multiple system atrophy is accounted for by shared brainstem neuropathology and likely identifies patients in a more advanced stage of disease. Excessive daytime sleepiness is found exclusively in PD and may be secondary to levodopa treatment and not related to α-synuclein disease. Eckhardt C, Fanciulli A, Högl B, et al. Analysis of sleep, daytime sleepiness, and autonomic function and multiple system atrophy and Parkinson disease: a prospective study.

Identifiants

pubmed: 36004744
pii: jcsm.10268
doi: 10.5664/jcsm.10268
pmc: PMC9806784
doi:

Substances chimiques

Levodopa 46627O600J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

63-71

Informations de copyright

© 2023 American Academy of Sleep Medicine.

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Auteurs

Christine Eckhardt (C)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Alessandra Fanciulli (A)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Birgit Högl (B)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Anna Heidbreder (A)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Sabine Eschlböck (S)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Cecilia Raccagni (C)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Department of Neurology, Regional Hospital of Bolzano, Bolzano, Italy.

Florian Krismer (F)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Fabian Leys (F)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Stefan Kiechl (S)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
VASCage, Research Centre on Vascular Ageing and Stroke, Innsbruck, Austria.

Gerhard Ransmayr (G)

Medical Faculty, Johannes Kepler University, Linz, Austria.

Birgit Frauscher (B)

Analytical Neurophysiology Lab and Epilepsy Program, Montreal Neurological Institute and Hospital, McGill University, Montreal H3A 2B4, Quebec, Canada.

Klaus Seppi (K)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Gregor Wenning (G)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Ambra Stefani (A)

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

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Classifications MeSH