Liquid Crystal Biosensors: Principles, Structure and Applications.
LC-based biosensors
liquid crystals
microfluidics
optofluidic
whispering gallery mode
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
14 Aug 2022
14 Aug 2022
Historique:
received:
23
06
2022
revised:
06
08
2022
accepted:
12
08
2022
entrez:
25
8
2022
pubmed:
26
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Liquid crystals (LCs) have been widely used as sensitive elements to construct LC biosensors based on the principle that specific bonding events between biomolecules can affect the orientation of LC molecules. On the basis of the sensing interface of LC molecules, LC biosensors can be classified into three types: LC-solid interface sensing platforms, LC-aqueous interface sensing platforms, and LC-droplet interface sensing platforms. In addition, as a signal amplification method, the combination of LCs and whispering gallery mode (WGM) optical microcavities can provide higher detection sensitivity due to the extremely high quality factor and the small mode volume of the WGM optical microcavity, which enhances the interaction between the light field and biotargets. In this review, we present an overview of the basic principles, the structure, and the applications of LC biosensors. We discuss the important properties of LC and the principle of LC biosensors. The different geometries of LCs in the biosensing systems as well as their applications in the biological detection are then described. The fabrication and the application of the LC-based WGM microcavity optofluidic sensor in the biological detection are also introduced. Finally, challenges and potential research opportunities in the development of LC-based biosensors are discussed.
Identifiants
pubmed: 36005035
pii: bios12080639
doi: 10.3390/bios12080639
pmc: PMC9406233
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 61735011
Organisme : China Scholarship Council
ID : 202006250152
Organisme : EU Horizon 2020 MSCA
ID : 101008280
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