Polyketides with anti-inflammatory activity from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7.
Alternaria sp. HJT-Y7
Anti-inflammatory
Crassulaceae
Endophyte
Pleosporaceae
Polyketide
Rhodiola tibetica
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
01
06
2022
revised:
11
08
2022
accepted:
14
08
2022
pubmed:
26
8
2022
medline:
12
10
2022
entrez:
25
8
2022
Statut:
ppublish
Résumé
Seven undescribed polyketides with particular ortho-trisubstituted benzo[c]furan and benzo[c]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations.
Identifiants
pubmed: 36007665
pii: S0031-9422(22)00299-0
doi: 10.1016/j.phytochem.2022.113383
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Furans
0
Lipopolysaccharides
0
Oxepins
0
Polyketides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113383Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.