Blocking Na
Animals
NAV1.8 Voltage-Gated Sodium Channel
/ metabolism
Dogs
Atrial Fibrillation
/ physiopathology
Male
Myocardial Infarction
/ physiopathology
Disease Models, Animal
Heart Rate
/ drug effects
Action Potentials
Voltage-Gated Sodium Channel Blockers
/ pharmacology
Time Factors
Refractory Period, Electrophysiological
Heart Conduction System
/ physiopathology
Aniline Compounds
Furans
Atrial fibrillation
Cardiac conduction
Ganglionated plexi
Ischemia heart disease
NaV1.8
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
29 Oct 2024
29 Oct 2024
Historique:
received:
19
10
2023
accepted:
14
10
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
The role of Na Eighteen male beagles were randomly enrolled. Left anterior descending coronary artery was ligated to created myocardial infarction model. Four weeks after surgery, Na Administration of A-803,467 significantly increased sinus rate, shortened PR interval and increased ventricular rate during atrial fibrillation compared to control. A-803,467 also significantly shortened atrial effective refractory period, prolonged atrial fibrillation duration and increased the cumulative window of atrial vulnerability. A-803,467 suppressed the slowing of heart rate response to high-frequency electrical stimulation of the anterior right GP, which was used as the surrogate marker for GP function. Double staining of ChAT and Na Blocking Na
Sections du résumé
BACKGROUND
BACKGROUND
The role of Na
METHODS
METHODS
Eighteen male beagles were randomly enrolled. Left anterior descending coronary artery was ligated to created myocardial infarction model. Four weeks after surgery, Na
RESULTS
RESULTS
Administration of A-803,467 significantly increased sinus rate, shortened PR interval and increased ventricular rate during atrial fibrillation compared to control. A-803,467 also significantly shortened atrial effective refractory period, prolonged atrial fibrillation duration and increased the cumulative window of atrial vulnerability. A-803,467 suppressed the slowing of heart rate response to high-frequency electrical stimulation of the anterior right GP, which was used as the surrogate marker for GP function. Double staining of ChAT and Na
CONCLUSIONS
CONCLUSIONS
Blocking Na
Identifiants
pubmed: 39472780
doi: 10.1186/s12872-024-04261-8
pii: 10.1186/s12872-024-04261-8
doi:
Substances chimiques
NAV1.8 Voltage-Gated Sodium Channel
0
Voltage-Gated Sodium Channel Blockers
0
A 803467
0
Aniline Compounds
0
Furans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
605Subventions
Organisme : Natural Science Foundation of Shanghai Municipality
ID : 22ZR1411500
Organisme : Natural Science Foundation of Shanghai Municipality
ID : 22ZR1411500
Organisme : Fujian Provincial Natural Science Foundation of China
ID : 2023J011693
Organisme : Shanghai Municipal Key Clinical Specialty
ID : shslczdzk01701
Informations de copyright
© 2024. The Author(s).
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