A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation.
GPCR
Gq/11
MC4R
homodimer
melanocortin 4 receptor
obesity
signaling
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
21
06
2022
revised:
11
08
2022
accepted:
12
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the
Identifiants
pubmed: 36009013
pii: biom12081119
doi: 10.3390/biom12081119
pmc: PMC9405727
pii:
doi:
Substances chimiques
Carrier Proteins
0
MC4R protein, human
0
Receptor, Melanocortin, Type 4
0
setmelanotide
0
alpha-MSH
581-05-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
N Engl J Med. 2018 Apr 05;378(14):1302-1312
pubmed: 29617589
J Clin Invest. 2000 Jul;106(2):271-9
pubmed: 10903343
Annu Rev Pharmacol Toxicol. 2002;42:409-35
pubmed: 11807178
Nat Neurosci. 2005 May;8(5):571-8
pubmed: 15856065
Biol Pharm Bull. 2012;35(12):2103-11
pubmed: 23207763
Peptides. 2005 Oct;26(10):1842-7
pubmed: 15982783
JAMA. 2020 Sep 1;324(9):879-887
pubmed: 32870301
N Engl J Med. 2016 Jun 23;374(25):2430-40
pubmed: 27074389
EMBO Rep. 2004 Jan;5(1):30-4
pubmed: 14710183
Surg Obes Relat Dis. 2021 Aug;17(8):1449-1456
pubmed: 34083135
Trends Mol Med. 2019 Feb;25(2):136-148
pubmed: 30642682
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3103-7
pubmed: 8385357
Science. 2013 Jul 19;341(6143):278-81
pubmed: 23869017
J Biol Chem. 1993 Jul 15;268(20):15174-9
pubmed: 8392067
Methods Mol Biol. 1992;8:153-8
pubmed: 21390709
Science. 2021 May 21;372(6544):808-814
pubmed: 33858992
Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970
pubmed: 33137293
Nat Med. 2018 May;24(5):551-555
pubmed: 29736023
Mol Metab. 2017 Oct;6(10):1321-1329
pubmed: 29031731
Int J Obes (Lond). 2011 Mar;35(3):457-61
pubmed: 20733581
Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29144-29154
pubmed: 33148803
Int J Mol Sci. 2020 Feb 12;21(4):
pubmed: 32059383
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5754-8
pubmed: 6777774
Int J Mol Sci. 2020 Aug 10;21(16):
pubmed: 32785054
J Cell Biol. 2011 Feb 7;192(3):463-80
pubmed: 21300851
J Biol Chem. 2014 Aug 29;289(35):24250-62
pubmed: 24966326
Cell Res. 2021 Nov;31(11):1176-1189
pubmed: 34561620
J Clin Invest. 2016 Jan;126(1):40-9
pubmed: 26595811
N Engl J Med. 2016 Jul 21;375(3):240-6
pubmed: 27468060
Front Endocrinol (Lausanne). 2019 Jul 31;10:515
pubmed: 31417496
J Biol Chem. 1994 Jan 28;269(4):2814-9
pubmed: 8300614
Obes Facts. 2009;2(2):80-6
pubmed: 20054210
J Mol Endocrinol. 2013 Jun 29;51(1):109-18
pubmed: 23674133
J Gen Virol. 1977 Jul;36(1):59-74
pubmed: 886304
Nat Rev Endocrinol. 2019 May;15(5):288-298
pubmed: 30814686
J Clin Invest. 2000 Jul;106(2):253-62
pubmed: 10903341
Obesity (Silver Spring). 2016 Sep;24(9):1976-82
pubmed: 27474872
Mol Pharmacol. 2017 Oct;92(4):414-424
pubmed: 28679508
Diabetes. 2003 Dec;52(12):2984-8
pubmed: 14633860
J Endocrinol. 2014 Oct;223(1):T63-70
pubmed: 25232148
Nature. 1998 Mar 26;392(6674):398-401
pubmed: 9537324
Lancet. 2017 Dec 16;390(10113):2627-2642
pubmed: 29029897