Molecular Dynamic Simulation Reveals Structure Differences in
APOL1
chronic kidney disease
molecular docking
molecular dynamic simulation
mutation
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
16 08 2022
16 08 2022
Historique:
received:
02
06
2022
revised:
28
07
2022
accepted:
08
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
According to observational studies, two polymorphisms in the apolipoprotein L1 ( To predict the active site and allosteric site on the According to CASTp's active site characterization, the topmost predicted site had a surface area of 964.892 Å Using a combination of different computational techniques, we identified binding sites within the
Sections du résumé
BACKGROUND
According to observational studies, two polymorphisms in the apolipoprotein L1 (
METHODS
To predict the active site and allosteric site on the
RESULTS
According to CASTp's active site characterization, the topmost predicted site had a surface area of 964.892 Å
CONCLUSION
Using a combination of different computational techniques, we identified binding sites within the
Identifiants
pubmed: 36011371
pii: genes13081460
doi: 10.3390/genes13081460
pmc: PMC9408642
pii:
doi:
Substances chimiques
APOL1 protein, human
0
Apolipoprotein L1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 220740/Z/20/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 214205/Z/18/Z
Pays : United Kingdom
Organisme : FIC NIH HHS
ID : D43 TW010045
Pays : United States
Organisme : FIC NIH HHS
ID : U2R TW010672
Pays : United States
Références
Front Pharmacol. 2021 Nov 30;12:751032
pubmed: 34916935
ACS Med Chem Lett. 2020 Oct 20;11(12):2352-2353
pubmed: 33335649
Biosci Rep. 2017 Apr 28;37(2):
pubmed: 28385815
Am J Nephrol. 2021;52(2):98-107
pubmed: 33752206
PLoS One. 2015 Mar 27;10(3):e0119264
pubmed: 25816325
Biochimie. 2021 Jan;180:104-120
pubmed: 33164889
Hemodial Int. 2021 Apr;25(2):173-179
pubmed: 33103356
Annu Rev Physiol. 2020 Feb 10;82:323-342
pubmed: 31710572
J Am Soc Nephrol. 2017 Apr;28(4):1008-1011
pubmed: 28196842
BMC Nephrol. 2018 Jun 1;19(1):125
pubmed: 29859046
Bioinformatics. 2007 Aug 1;23(15):1875-82
pubmed: 17519246
Chem Biodivers. 2021 Sep;18(9):e2100204
pubmed: 34252268
Mach Learn Sci Technol. 2021 Sep;2(3):
pubmed: 34396127
FEBS J. 2021 Jan;288(2):360-381
pubmed: 32530132
Adv Exp Med Biol. 2019;1165:3-15
pubmed: 31399958
BMC Res Notes. 2021 Dec 20;14(1):457
pubmed: 34930451
PLoS Negl Trop Dis. 2016 Aug 05;10(8):e0004903
pubmed: 27494254
Curr Opin Pediatr. 2018 Apr;30(2):252-259
pubmed: 29406442
J Chem Phys. 2014 May 7;140(17):174501
pubmed: 24811640
Hum Mol Genet. 2021 Apr 26;30(R1):R129-R137
pubmed: 33744923
Kidney Int Rep. 2022 Jan 25;7(4):786-796
pubmed: 35497797