Protease Profile of Tumor-Associated Mast Cells in Melanoma.
carboxypeptidases
chymase
mast cells
melanoma
tryptase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Aug 2022
11 Aug 2022
Historique:
received:
26
07
2022
revised:
07
08
2022
accepted:
08
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Mast cells (MCs) produce a variety of mediators, including proteases-tryptase, chymase, and carboxypeptidases-which are important for the immune response. However, a detailed assessment of the mechanisms of biogenesis and excretion of proteases in melanoma has yet to be carried out. In this study, we present data on phenotype and secretory pathways of proteases in MCs in the course of melanoma. The development of melanoma was found to be accompanied by the appearance in the tumor-associated MC population of several pools with a predominant content of one or two specific proteases with a low content or complete absence of others. Elucidation of the molecular and morphological features of the expression of MC proteases in melanoma allows us a fresh perspective of the pathogenesis of the disease, and can be used to clarify MCs classification, the disease prognosis, and evaluate the effectiveness of ongoing antitumor therapy.
Identifiants
pubmed: 36012196
pii: ijms23168930
doi: 10.3390/ijms23168930
pmc: PMC9408654
pii:
doi:
Substances chimiques
Carboxypeptidases
EC 3.4.-
Peptide Hydrolases
EC 3.4.-
Chymases
EC 3.4.21.39
Tryptases
EC 3.4.21.59
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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