Congo Red as a Supramolecular Carrier System for Doxorubicin: An Approach to Understanding the Mechanism of Action.
Langmuir films
Raman spectroscopy
doxorubicin
drug carrier
drug–membrane interactions
molecular dynamics simulations
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Aug 2022
11 Aug 2022
Historique:
received:
27
07
2022
revised:
06
08
2022
accepted:
09
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
The uptake and distribution of doxorubicin in the MCF7 line of breast-cancer cells were monitored by Raman measurements. It was demonstrated that bioavailability of doxorubicin can be significantly enhanced by applying Congo red. To understand the mechanism of doxorubicin delivery by Congo red supramolecular carriers, additional monolayer measurements and molecular dynamics simulations on model membranes were undertaken. Acting as molecular scissors, Congo red particles cut doxorubicin aggregates and incorporated them into small-sized Congo red clusters. The mixed doxorubicin/Congo red clusters were adsorbed to the hydrophilic part of the model membrane. Such behavior promoted transfer through the membrane.
Identifiants
pubmed: 36012200
pii: ijms23168935
doi: 10.3390/ijms23168935
pmc: PMC9408855
pii:
doi:
Substances chimiques
Excipients
0
Congo Red
3U05FHG59S
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Centre for Research and Development
ID : POWR.03.02.00-00-I013/16
Organisme : National Science Center
ID : 2016/21/D/NZ1/02763
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