Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs).
circulating MSCs
exosomes
immunomodulation
inflammation
innate immunity
mesenchymal stem cells
miRNA
pericytes
perivascular MSCs
sepsis
septic shock
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Aug 2022
17 Aug 2022
Historique:
received:
31
07
2022
revised:
14
08
2022
accepted:
15
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
The treatment of sepsis and septic shock remains a major public health issue due to the associated morbidity and mortality. Despite an improvement in the understanding of the physiological and pathological mechanisms underlying its genesis and a growing number of studies exploring an even higher range of targeted therapies, no significant clinical progress has emerged in the past decade. In this context, mesenchymal stem cells (MSCs) appear more and more as an attractive approach for cell therapy both in experimental and clinical models. Pre-clinical data suggest a cornerstone role of these cells and their secretome in the control of the host immune response. Host-derived factors released from infected cells (i.e., alarmins, HMGB1, ATP, DNA) as well as pathogen-associated molecular patterns (e.g., LPS, peptidoglycans) can activate MSCs located in the parenchyma and around vessels to upregulate the expression of cytokines/chemokines and growth factors that influence, respectively, immune cell recruitment and stem cell mobilization. However, the way in which MSCs exert their beneficial effects in terms of survival and control of inflammation in septic states remains unclear. This review presents the interactions identified between MSCs and mediators of immunity and tissue repair in sepsis. We also propose paradigms related to the plausible roles of MSCs in the process of sepsis and septic shock. Finally, we offer a presentation of experimental and clinical studies and open the way to innovative avenues of research involving MSCs from a prognostic, diagnostic, and therapeutic point of view in sepsis.
Identifiants
pubmed: 36012544
pii: ijms23169274
doi: 10.3390/ijms23169274
pmc: PMC9409099
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Clin Exp Med. 2013 Aug;13(3):165-70
pubmed: 22644264
J Neuroimmune Pharmacol. 2020 Dec;15(4):838-851
pubmed: 32964324
Transl Res. 2018 Mar;193:42-53
pubmed: 29324234
Engineering (Beijing). 2020 Oct;6(10):1153-1161
pubmed: 32292627
J Extracell Vesicles. 2016 Nov 17;5:32570
pubmed: 27863537
Stem Cell Res Ther. 2020 Jun 3;11(1):214
pubmed: 32493435
Immunity. 2010 Nov 24;33(5):657-70
pubmed: 21094463
Stem Cells. 2017 Dec;35(12):2331-2339
pubmed: 28856759
Cell Commun Signal. 2016 Jan 12;14:2
pubmed: 26754424
Stem Cells. 2005 Sep;23(8):1105-12
pubmed: 15955825
Stem Cells. 2016 Dec;34(12):2943-2955
pubmed: 27350036
Cell Mol Life Sci. 2019 Jun;76(11):2031-2042
pubmed: 30877336
Lancet. 2005 Jul 16-22;366(9481):249-60
pubmed: 16023517
Stem Cells Int. 2019 Sep 9;2019:7132708
pubmed: 31582986
PLoS One. 2007 Sep 26;2(9):e941
pubmed: 17895982
Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L846-56
pubmed: 22345572
Science. 2011 Oct 7;334(6052):98-101
pubmed: 21921156
Tissue Eng Regen Med. 2022 Aug;19(4):659-673
pubmed: 35384633
Crit Care Med. 2007 Dec;35(12):2693-2701
pubmed: 18074471
Nat Commun. 2013;4:2823
pubmed: 24264436
Front Immunol. 2017 Nov 02;8:1452
pubmed: 29163522
Crit Care Med. 2001 Mar;29(3):503-10
pubmed: 11373411
J Orthop Res. 2017 Jun;35(6):1151-1159
pubmed: 28294393
Annu Rev Immunol. 2011;29:139-62
pubmed: 21219181
Brain Behav Immun. 2002 Aug;16(4):290-332
pubmed: 12096881
J Immunol. 2010 Mar 1;184(5):2321-8
pubmed: 20130212
Adv Biochem Eng Biotechnol. 2010;123:1-27
pubmed: 20237903
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Stem Cell Res Ther. 2011 Aug 11;2(4):34
pubmed: 21861858
J Matern Fetal Neonatal Med. 2018 Aug;31(16):2209-2215
pubmed: 28562124
Front Immunol. 2020 Mar 10;11:407
pubmed: 32210974
PLoS One. 2010 Dec 07;5(12):e14247
pubmed: 21151872
Cytotherapy. 2005;7(5):393-5
pubmed: 16236628
Stem Cells. 2018 Mar;36(3):434-445
pubmed: 29239062
Int J Infect Dis. 2020 Jun;95:1-7
pubmed: 32251795
BMC Pediatr. 2018 Mar 23;18(1):118
pubmed: 29571293
Trends Biotechnol. 2006 Apr;24(4):150-4
pubmed: 16488036
J Mol Med (Berl). 2018 Dec;96(12):1387-1394
pubmed: 30357435
Cell Transplant. 2015;24(3):339-47
pubmed: 25622293
Immunol Rev. 2006 Aug;212:8-27
pubmed: 16903903
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1410-5
pubmed: 23297238
Development. 2004 Oct;131(19):4637-50
pubmed: 15358668
Intensive Care Med. 2000 Mar;26 Suppl 2:S212-6
pubmed: 18470722
N Engl J Med. 2001 Mar 8;344(10):699-709
pubmed: 11236773
Blood. 2005 Sep 1;106(5):1755-61
pubmed: 15905186
Biochem Biophys Res Commun. 2019 Mar 19;510(4):565-572
pubmed: 30739785
Nat Rev Immunol. 2013 Mar;13(3):159-75
pubmed: 23435331
J Immunol. 2017 Sep 15;199(6):1961-1966
pubmed: 28768726
Inflamm Res. 2015 Feb;64(2):127-35
pubmed: 25561369
Anesthesiology. 2016 Jul;125(1):237-49
pubmed: 27183167
Br J Pharmacol. 2010 Jan 1;159(2):253-64
pubmed: 20002097
Front Immunol. 2019 Sep 20;10:2179
pubmed: 31616411
Br J Anaesth. 2017 Mar 1;118(3):283-286
pubmed: 28203722
Front Biosci. 2004 May 01;9:1201-17
pubmed: 14977537
Am J Respir Crit Care Med. 2018 Jan 1;197(1):104-116
pubmed: 28853608
J Innate Immun. 2013;5(4):304-14
pubmed: 23571274
Eur J Intern Med. 2017 Nov;45:46-50
pubmed: 28965741
Blood. 2006 Sep 15;108(6):2114-20
pubmed: 16690970
Shock. 2013 Nov;40(5):358-65
pubmed: 24088989
Immunol Lett. 2012 Sep;147(1-2):47-54
pubmed: 22705267
Nature. 2010 Aug 12;466(7308):829-34
pubmed: 20703299
Crit Care Med. 2005 Dec;33(12 Suppl):S514-6
pubmed: 16340437
Sci Rep. 2018 Apr 26;8(1):6621
pubmed: 29700315
Ann Am Thorac Soc. 2013 Oct;10(5):S25-44
pubmed: 23869447
J Immunol. 2008 May 1;180(9):6334-45
pubmed: 18424757
Crit Care. 2014 Sep 16;18(5):511
pubmed: 25223540
Transl Res. 2018 Sep;199:52-61
pubmed: 30044959
J Exp Med. 2013 Oct 21;210(11):2321-36
pubmed: 24081949
Crit Care. 2016 Nov 28;20(1):383
pubmed: 27890015
Int J Hematol. 2021 Jan;113(1):24-33
pubmed: 33386597
Lancet Infect Dis. 2013 May;13(5):426-35
pubmed: 23375419
Stem Cell Res Ther. 2019 Nov 28;10(1):359
pubmed: 31779700
Crit Care Med. 2013 May;41(5):1167-74
pubmed: 23442987
Clin Chem Lab Med. 2014 Oct;52(10):1395-400
pubmed: 24897403
Medicine (Baltimore). 2020 Jul 31;99(31):e21429
pubmed: 32756149
Clin Chem. 2004 Aug;50(8):1301-14
pubmed: 15166107
Inflammation. 2021 Dec;44(6):2143-2150
pubmed: 34291398
Crit Care Med. 1997 Jul;25(7):1115-24
pubmed: 9233735
Curr Vasc Pharmacol. 2013 Mar 1;11(2):150-60
pubmed: 23506494
Stem Cells Dev. 2020 Jun 15;29(12):747-754
pubmed: 32380908
Liver Int. 2013 Jul;33(6):834-42
pubmed: 23590253
Crit Care Med. 2019 Jul;47(7):918-925
pubmed: 30720538
Crit Care. 2010;14(1):R15
pubmed: 20144219
Nat Rev Immunol. 2017 Jul;17(7):407-420
pubmed: 28436424
Stem Cells. 2018 Apr;36(4):602-615
pubmed: 29341339
J Clin Invest. 2010 Jul;120(7):2423-31
pubmed: 20516641
Immunology. 2014 Sep 8;:
pubmed: 25201453
J Lipid Res. 2019 Feb;60(2):318-322
pubmed: 30154233
Respir Res. 2014 Apr 04;15:39
pubmed: 24708472
Am J Physiol Lung Cell Mol Physiol. 2000 May;278(5):L880-7
pubmed: 10781417
J Infect Dis. 2017 May 15;215(10):1608-1618
pubmed: 28368519
Cardiovasc Res. 1996 Oct;32(4):687-98
pubmed: 8915187
J Cell Mol Med. 2017 Sep;21(9):1687-1697
pubmed: 28244690
Leukemia. 2006 Nov;20(11):1915-24
pubmed: 16900209
Dev Biol. 2018 Dec 1;444 Suppl 1:S25-S35
pubmed: 29454705
Cancer Sci. 2020 Sep;111(9):3100-3110
pubmed: 32639675
Cancer Res. 2007 Dec 15;67(24):11687-95
pubmed: 18089798
Crit Care Med. 2007 Jul;35(7):1677-84
pubmed: 17522579
Pharmacol Rev. 2000 Dec;52(4):595-638
pubmed: 11121511
Stem Cells. 2017 Jul;35(7):1747-1759
pubmed: 28376567
Intensive Care Med. 2010 Aug;36(8):1286-98
pubmed: 20443110
Dev Biol. 2012 Jun 1;366(1):83-95
pubmed: 22425619
Elife. 2014 Sep 25;3:e03696
pubmed: 25255216
Intensive Care Med. 2009 Apr;35(4):587-95
pubmed: 18936908
Cell Tissue Kinet. 1987 May;20(3):263-72
pubmed: 3690622
Blood. 2007 Jan 1;109(1):228-34
pubmed: 16985180
Mol Neurobiol. 2016 Dec;53(10):6635-6643
pubmed: 26637327
Cerebrovasc Dis. 2009;27 Suppl 1:25-37
pubmed: 19342831
Sci Rep. 2018 Oct 19;8(1):15550
pubmed: 30341325
Intensive Care Med Exp. 2018 Aug 8;6(1):24
pubmed: 30091119
N Engl J Med. 2020 Jul 16;383(3):218-228
pubmed: 32668112
Nat Rev Genet. 2014 Jun;15(6):423-37
pubmed: 24776770
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Feb;21(1):227-30
pubmed: 23484725
J Orthop Res. 1991 Sep;9(5):641-50
pubmed: 1870029
Stem Cells. 2006 Jan;24(1):74-85
pubmed: 16099998
Lancet. 2008 May 10;371(9624):1579-86
pubmed: 18468541
Crit Care Med. 2013 Mar;41(3):706-16
pubmed: 23425819
Lancet Respir Med. 2015 Jan;3(1):24-32
pubmed: 25529339
Cell. 2007 Jun 29;129(7):1377-88
pubmed: 17604725
Int J Dev Neurosci. 2012 Oct;30(6):471-7
pubmed: 22683696
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
Clin Vaccine Immunol. 2013 Sep;20(9):1396-404
pubmed: 23825193
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
BMC Pulm Med. 2020 Nov 25;20(1):309
pubmed: 33238991
Crit Care. 2013 Jul 30;17(4):R168
pubmed: 23899120
J Extracell Vesicles. 2016 Jul 05;5:30741
pubmed: 27389011
Cytometry A. 2018 Jan;93(1):19-31
pubmed: 29072818
Oncoimmunology. 2015 Aug 12;5(4):e1071008
pubmed: 27141373
Cell Stem Cell. 2008 Sep 11;3(3):301-13
pubmed: 18786417
PLoS One. 2020 Jan 27;15(1):e0227460
pubmed: 31986159
Blood. 2004 Jul 15;104(2):565-71
pubmed: 15054039
Curr Opin Immunol. 2005 Aug;17(4):359-65
pubmed: 15955682
Crit Care Med. 2010 Aug;38(8):1685-94
pubmed: 20562702
Exp Hematol. 2002 Jan;30(1):42-8
pubmed: 11823036
Nature. 2002 Dec 19-26;420(6917):853-9
pubmed: 12490958
Cell Death Differ. 2015 Jul;22(7):1219-30
pubmed: 25571972
Am J Physiol Renal Physiol. 2005 Jul;289(1):F31-42
pubmed: 15713913
Cardiovasc Res. 2019 Jun 1;115(7):1205-1216
pubmed: 30753344
Intensive Care Med. 2015 Sep;41(9):1549-60
pubmed: 25952825
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Thromb Res. 2017 Jan;149:38-44
pubmed: 27886531
PLoS One. 2014 May 05;9(5):e93846
pubmed: 24796678
Clin Chem Lab Med. 2009;47(8):903-16
pubmed: 19642859
Intensive Care Med. 2002 Mar;28(3):235-43
pubmed: 11904651
Intensive Care Med. 2013 Feb;39(2):165-228
pubmed: 23361625
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11002-7
pubmed: 17569781
Stem Cells. 2004;22(4):625-34
pubmed: 15277708
ACS Nano. 2019 Jun 25;13(6):6670-6688
pubmed: 31117376
Annu Rev Immunol. 2018 Apr 26;36:783-812
pubmed: 29677475
Front Immunol. 2017 Mar 30;8:339
pubmed: 28424688
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):54-60
pubmed: 17991877
Intensive Care Med Exp. 2020 Dec 18;8(Suppl 1):20
pubmed: 33336293
Anesth Analg. 2009 Jun;108(6):1841-7
pubmed: 19448210
JAMA. 2016 Feb 23;315(8):775-87
pubmed: 26903336
Cell. 2007 Oct 19;131(2):324-36
pubmed: 17956733
Endocrinology. 2003 Dec;144(12):5578-84
pubmed: 12960010
Immunology. 2001 Jul;103(3):281-90
pubmed: 11454057
Int J Mol Sci. 2014 Aug 18;15(8):14348-63
pubmed: 25196436
Mol Ther. 2012 Jan;20(1):14-20
pubmed: 22008910
Cells Tissues Organs. 2001;169(1):12-20
pubmed: 11340257
Sci Rep. 2016 Apr 13;6:24120
pubmed: 27071676
J Immunol. 2010 Dec 1;185(11):6608-16
pubmed: 21048109
Front Immunol. 2020 Feb 07;11:126
pubmed: 32117276
J Leukoc Biol. 2015 Dec;98(6):1081-90
pubmed: 26224052
Crit Care Med. 2020 May;48(5):e391-e399
pubmed: 32187077
J Infect. 2016 Nov;73(5):402-418
pubmed: 27546064
World J Emerg Med. 2020;11(2):79-86
pubmed: 32076472
Crit Care Med. 2020 May;48(5):e409-e417
pubmed: 32167490
J Cell Biol. 2001 May 28;153(5):1133-40
pubmed: 11381097
Intensive Care Med. 2004 Apr;30(4):580-8
pubmed: 14997295
FEBS Lett. 2015 May 8;589(11):1257-65
pubmed: 25862500
Cell Death Dis. 2015 Nov 19;6:e1989
pubmed: 26583329
Diabetologia. 2016 Feb;59(2):325-33
pubmed: 26592240
J Infect. 2015 Oct;71(4):413-21
pubmed: 26092350
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
J Infect. 2017 Oct;75(4):281-292
pubmed: 28778751
Blood. 2005 Dec 15;106(13):4057-65
pubmed: 16118325
Am J Obstet Gynecol. 2014 Oct;211(4):380.e1-13
pubmed: 24657793
Lancet Respir Med. 2019 Feb;7(2):154-162
pubmed: 30455077
Stem Cells. 2006 Apr;24(4):928-35
pubmed: 16306150
Mol Neurobiol. 2018 Feb;55(2):1045-1053
pubmed: 28092082
Shock. 2015 Feb;43(2):121-7
pubmed: 25394245
Cell Stem Cell. 2008 Apr 10;2(4):313-9
pubmed: 18397751
Shock. 2001 Aug;16(2):83-96
pubmed: 11508871
Stem Cells. 2009 Mar;27(3):693-702
pubmed: 19096038
Shock. 2003 Nov;20(5):386-401
pubmed: 14560102
Nat Rev Immunol. 2009 Aug;9(8):581-93
pubmed: 19498381
Nat Rev Mol Cell Biol. 2014 Aug;15(8):509-24
pubmed: 25027649
Mol Cell. 2002 Aug;10(2):417-26
pubmed: 12191486
Circ Res. 2008 Jan 4;102(1):77-85
pubmed: 17967785
Stem Cells. 2008 Sep;26(9):2287-99
pubmed: 18566331
JAMA. 2011 Dec 21;306(23):2594-605
pubmed: 22187279
J Immunol. 2013 Mar 1;190(5):1991-2000
pubmed: 23355736
Crit Care. 2016 Jan 20;20:15
pubmed: 26786705
Mol Oncol. 2018 Nov;12(11):1935-1948
pubmed: 30107086
Trends Immunol. 2012 Mar;33(3):136-43
pubmed: 22227317
Shock. 2016 Mar;45(3):259-70
pubmed: 26871664
PLoS One. 2014 Jun 11;9(2):e98819
pubmed: 24919177
Cell Stem Cell. 2009 Mar 6;4(3):206-16
pubmed: 19265660
Stem Cells Dev. 2014 Jun 1;23(11):1233-44
pubmed: 24367916
Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):697-705
pubmed: 18831938
Crit Care Med. 2013 Mar;41(3):820-32
pubmed: 23348516
Am J Respir Crit Care Med. 2015 Aug 1;192(3):324-36
pubmed: 26067592
Transplantation. 2003 Feb 15;75(3):389-97
pubmed: 12589164
J Antimicrob Chemother. 2011 Apr;66 Suppl 2:ii33-40
pubmed: 21398306
Crit Care Med. 1992 Jun;20(6):864-74
pubmed: 1597042
Stem Cells Dev. 2016 Dec 15;25(24):1874-1883
pubmed: 27649744
Stem Cells. 2016 Mar;34(3):601-13
pubmed: 26782178
Cell Tissue Res. 2018 Oct;374(1):1-15
pubmed: 29955951
Dis Markers. 2009;27(3):157-72
pubmed: 19893210
J Leukoc Biol. 2018 Feb;103(2):295-309
pubmed: 29345350
Cytotherapy. 2017 Dec;19(12):1351-1382
pubmed: 28964742
Crit Rev Immunol. 2015;35(4):277-91
pubmed: 26757392
J Immunol. 2007 Oct 15;179(8):5082-9
pubmed: 17911593
Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347
pubmed: 28960096
Crit Care Med. 2007 Dec;35(12):2762-8
pubmed: 17901837
Nat Rev Immunol. 2014 May;14(5):302-14
pubmed: 24751955
Stem Cells. 2006 Oct;24(10):2202-8
pubmed: 16778152
Hum Gene Ther. 2010 Jun;21(6):713-27
pubmed: 20102275
Stem Cells. 2018 Nov;36(11):1778-1788
pubmed: 30063804
J Cell Physiol. 2020 Oct;235(10):7043-7055
pubmed: 32043593
Endocrinology. 2005 Jun;146(6):2699-708
pubmed: 15761041
FASEB J. 2011 May;25(5):1758-66
pubmed: 21285396
Ann Neurol. 2007 Mar;61(3):219-27
pubmed: 17387730
Shock. 2017 Dec;48(6):600-609
pubmed: 28520694
J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13
pubmed: 16684817
Cell. 2003 Sep 19;114(6):763-76
pubmed: 14505575
Biomaterials. 2018 Feb;156:16-27
pubmed: 29182933
J Immunol. 2017 Mar 15;198(6):2403-2413
pubmed: 28188248
PLoS One. 2015 Aug 19;10(8):e0136175
pubmed: 26288180
Stem Cell Res Ther. 2019 Jun 27;10(1):192
pubmed: 31248453
Nat Rev Immunol. 2012 Apr 25;12(5):383-96
pubmed: 22531326
Blood. 2005 May 15;105(10):3793-801
pubmed: 15677562
Stem Cells. 2006 Apr;24(4):1030-41
pubmed: 16253981
Crit Care. 2019 May 31;23(1):196
pubmed: 31151462
Am J Respir Crit Care Med. 2013 Aug 1;188(3):370-5
pubmed: 23713908
J Immunol. 2011 Jul 15;187(2):911-8
pubmed: 21690321
Mol Med. 2008 Jan-Feb;14(1-2):64-78
pubmed: 18026569
J Mol Neurosci. 2019 Nov;69(3):351-359
pubmed: 31264051
Crit Care Med. 2018 Dec;46(12):1889-1897
pubmed: 30048332
Stem Cells. 2007 Jan;25(1):69-77
pubmed: 16973831
Nat Biotechnol. 2016 Oct;34(10):1066-1071
pubmed: 27617738
PLoS One. 2017 Dec 12;12(12):e0188882
pubmed: 29232699
BMC Infect Dis. 2014 Mar 26;14:166
pubmed: 24669841
Crit Care. 2015 Aug 28;19:286
pubmed: 26316210
Int J Biochem Cell Biol. 2008;40(5):815-20
pubmed: 18295530
J Clin Invest. 2014 Dec;124(12):5503-15
pubmed: 25401473
Nat Rev Immunol. 2021 Jan;21(1):20-36
pubmed: 32811994
Stem Cells Int. 2016;2016:1240301
pubmed: 27843457