The Omnipresence of DYRK1A in Human Diseases.

Disease Humans Protein Serine-Threonine Kinases / genetics Protein-Tyrosine Kinases / genetics Dyrk Kinases
DYRK1A cancers diabetes heart diseases neurodegenerative diseases protein kinase viral infections

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Aug 2022
Historique:
received: 07 07 2022
revised: 11 08 2022
accepted: 17 08 2022
entrez: 26 8 2022
pubmed: 27 8 2022
medline: 30 8 2022
Statut: epublish

Résumé

The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.

Identifiants

DOI: 10.3390/ijms23169355 PMID: 36012629 PMC: PMC9408930
pubmed: 36012629
pii: ijms23169355
doi: 10.3390/ijms23169355
pmc: PMC9408930
pii:
doi:

Substances chimiques

Protein-Tyrosine Kinases EC 2.7.10.1
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : R01 AG067926
Pays : United States
Organisme : Edson Family Foundation
ID : GR38526

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Auteurs

Estelle Deboever (E)

ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
ORCID: 0000-0001-5707-9483

Alessandra Fistrovich (A)

Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, AZ 85721, USA.
Division of Drug Discovery and Development, Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.

Christopher Hulme (C)

Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, AZ 85721, USA.
Division of Drug Discovery and Development, Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.

Travis Dunckley (T)

ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Maladie › The Omnipresence of DYRK1A in Human Diseases.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Omnipresence of DYRK1A in Human Diseases.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › The Omnipresence of DYRK1A in Human Diseases.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › The Omnipresence of DYRK1A in Human Diseases.