Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update.
aging
clinical implications
coagulation factors
elderly
pathophysiological changes
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
10 Aug 2022
10 Aug 2022
Historique:
received:
08
07
2022
revised:
03
08
2022
accepted:
07
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
The aim of this review is to highlight all the factors that associate venous thromboembolism (VTE) with aging. Elderly people are characterized by a higher incidence of thrombosis taking into account the co-existing comorbidities, complications and fatality that arise. Based on the Virchow triad, pathophysiological aspects of venous stasis, endothelium injury and hypercoagulability in elderly people (≥65 years) are described in detail. More precisely, venous wall structure, nitric oxide (NO) and endothelin-1 expression are impaired in this age group. Furthermore, an increase in high-molecular-weight kininogen (HMWK), prekallikrein, factors V, VII, VIII, IX and XI, clot lysis time (CLT) and von Willebrand factor (vWF) is observed. Age-dependent platelet dysfunction and changes in anticoagulant factors are also illustrated. A "low-grade inflammation stage" is delineated as a possible risk factor for thrombosis in the elderly. Consequently, clinical implications for frail elderly people related to diagnosis, treatment, bleeding danger and VTE recurrence emerge. We conclude that aging is an acquired thrombotic factor closely related to pathophysiological changes.
Identifiants
pubmed: 36013544
pii: medicina58081078
doi: 10.3390/medicina58081078
pmc: PMC9415158
pii:
doi:
Substances chimiques
von Willebrand Factor
0
Factor V
9001-24-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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