Different Protein Sources Enhance 18FDG-PET/MR Uptake of Brown Adipocytes in Male Subjects.
animal protein
brain natriuretic peptide
brown adipose tissue
muscle mass
plant protein
visceral adipose tissue
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Aug 2022
19 Aug 2022
Historique:
received:
14
07
2022
revised:
13
08
2022
accepted:
16
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
The unique ability of brown adipocytes to increase metabolic rate suggests that they could be targeted as an obesity treatment. The objective of the study was to search for new dietary factors that may enhance brown adipose tissue (BAT) activity. The study group comprised 28 healthy non-smoking males, aged 21-42 years old. All volunteers underwent a physical examination and a 75 g oral glucose tolerance test (75g-OGTT). Serum atrial and brain natriuretic peptide (ANP, BNP), PRD1-BF1-RIZ1 homologous domain containing 16 (PRDM16) and eukaryotic translation initiation factor 4E (eIF4E) measurements were taken, and 3-day food intake diaries were completed. Body composition measurements were assessed using dual-energy X-ray absorptiometry (DXA) scanning and bioimpedance methods. An fluorodeoxyglucose-18 (FDG-18) uptake in BAT was assessed by positron emission tomography/magnetic resonance (PET/MR) in all participants after 2 h cold exposure. The results were adjusted for age, daily energy intake, and DXA lean mass. Subjects with detectable BAT (BAT The outcomes of our study suggest that different macronutrient consumption may be a new way to modulate BAT activity leading to weight reduction.
Sections du résumé
BACKGROUND
BACKGROUND
The unique ability of brown adipocytes to increase metabolic rate suggests that they could be targeted as an obesity treatment.
OBJECTIVE
OBJECTIVE
The objective of the study was to search for new dietary factors that may enhance brown adipose tissue (BAT) activity.
METHODS
METHODS
The study group comprised 28 healthy non-smoking males, aged 21-42 years old. All volunteers underwent a physical examination and a 75 g oral glucose tolerance test (75g-OGTT). Serum atrial and brain natriuretic peptide (ANP, BNP), PRD1-BF1-RIZ1 homologous domain containing 16 (PRDM16) and eukaryotic translation initiation factor 4E (eIF4E) measurements were taken, and 3-day food intake diaries were completed. Body composition measurements were assessed using dual-energy X-ray absorptiometry (DXA) scanning and bioimpedance methods. An fluorodeoxyglucose-18 (FDG-18) uptake in BAT was assessed by positron emission tomography/magnetic resonance (PET/MR) in all participants after 2 h cold exposure. The results were adjusted for age, daily energy intake, and DXA lean mass.
RESULTS
RESULTS
Subjects with detectable BAT (BAT
CONCLUSION
CONCLUSIONS
The outcomes of our study suggest that different macronutrient consumption may be a new way to modulate BAT activity leading to weight reduction.
Identifiants
pubmed: 36014915
pii: nu14163411
doi: 10.3390/nu14163411
pmc: PMC9413993
pii:
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : N/A
ID : N/A
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