Increased rates of fragrance allergy in fibromyalgia individuals tested with the Swedish baseline patch test series.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
29
03
2022
accepted:
27
07
2022
pubmed:
27
8
2022
medline:
16
12
2022
entrez:
26
8
2022
Statut:
ppublish
Résumé
Contact allergy can manifest in a variety of ways clinically. Systemic contact allergy may occasionally present with pain in muscles and joints. Fibromyalgia is a chronic rheumatic disease characterized by pain and with virtually unknown aetiology. The aim of this study was to investigate the contact allergy rates to the sensitizers in a baseline series and compare with corresponding rates in dermatitis patients and the general population. Patch testing with the Swedish baseline series was performed in 120 individuals with fibromyalgia. Fisher's exact test was used for pair-wise comparisons of contact allergy rates between the fibromyalgia group and two control groups, dermatitis patients and individuals in the general population. Contact allergy was significantly more common in the fibromyalgia group compared to the general population concerning nickel and the fragrance markers Myroxolon pereirae and fragrance mix I. There were fewer allergic reactions to preservatives in the fibromyalgia group compared with the dermatitis group. Myroxolon pereirae and fragrance mix I represent besides fragrance allergy also allergy to flavouring substances which indicate that oral exposure to flavouring substances and hygiene products might be important for sensitization and possibly elicitation of systemic contact allergy symptoms in fibromyalgia individuals.
Sections du résumé
BACKGROUND
BACKGROUND
Contact allergy can manifest in a variety of ways clinically. Systemic contact allergy may occasionally present with pain in muscles and joints. Fibromyalgia is a chronic rheumatic disease characterized by pain and with virtually unknown aetiology.
OBJECTIVES
OBJECTIVE
The aim of this study was to investigate the contact allergy rates to the sensitizers in a baseline series and compare with corresponding rates in dermatitis patients and the general population.
METHODS
METHODS
Patch testing with the Swedish baseline series was performed in 120 individuals with fibromyalgia. Fisher's exact test was used for pair-wise comparisons of contact allergy rates between the fibromyalgia group and two control groups, dermatitis patients and individuals in the general population.
RESULTS
RESULTS
Contact allergy was significantly more common in the fibromyalgia group compared to the general population concerning nickel and the fragrance markers Myroxolon pereirae and fragrance mix I. There were fewer allergic reactions to preservatives in the fibromyalgia group compared with the dermatitis group.
CONCLUSIONS
CONCLUSIONS
Myroxolon pereirae and fragrance mix I represent besides fragrance allergy also allergy to flavouring substances which indicate that oral exposure to flavouring substances and hygiene products might be important for sensitization and possibly elicitation of systemic contact allergy symptoms in fibromyalgia individuals.
Substances chimiques
Perfume
0
Allergens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-113Subventions
Organisme : Research Foundation of the Swedish Fibromyalgia Association
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 European Academy of Dermatology and Venereology.
Références
Pongpairoj K, Ale I, Andersen KE, Bruze M, Diepgen TL, Elsner PU, et al. Proposed ICDRG classification of the clinical presentation of contact allergy. Dermatitis. 2016;27(5):248-58.
Kulberg A, Schliemann S, Elsner P. Contact dermatitis as a systemic disease. Clin Dermatol. 2014;32(3):414-9.
Ekqvist S, Svedman C, Moller H, Kehler M, Pripp CM, Björk J, et al. High frequency of contact allergy to gold in patients with endovascular coronary stents. Br J Dermatol. 2007;157(4):730-8.
Svedman C, Ekqvist S, Möller H, Björk J, Pripp CM, Gruvberger B, et al. A correlation found between contact allergy to stent material and restenosis of the coronary arteries. Contact Dermatitis. 2009;60(3):158-64.
Moller H, Bjorkner B, Bruze M. Clinical reactions to systemic provocation with gold sodium thiomalate in patients with contact allergy to gold. Br J Dermatol. 1996;135(3):423-7.
Moller H, Ohlsson K, Linder C, Bjorkner B, Bruze M. The flare-up reactions after systemic provocation in contact allergy to nickel and gold. Contact Dermatitis. 1999;40(4):200-4.
Malinauskiene L, Isaksson M, Bruze M. Systemic contact dermatitis in a gold-allergic patient after treatment with an oral homeopathic drug. J Am Acad Dermatol. 2013;68(2):e58.
Ahnlide I, Ahlgren C, Björkner B, Bruze M, Lundh T, Möller H, et al. Gold concentration in blood in relation to the number of gold restorations and contact allergy to gold. Acta Odontol Scand. 2002;60(5):301-5.
Svedman C, Lundh T, Tillman C, Moller H, Gustavsson CG, Bruze M. Gold concentration in blood in patients with gold-plated stents. Contact Dermatitis. 2006;54(4):221-2.
Svedman C, Möller H, Gruvberger B, Gustavsson CG, Dahlin J, Persson L, et al. Implants and contact allergy: are sensitizing metals released as haptens from coronary stents? Contact Dermatitis. 2014;71(2):92-7.
Marcusson JA. Contact allergies to nickel sulfate, gold sodium thiosulfate and palladium chloride in patients claiming side-effects from dental alloy components. Contact Dermatitis. 1996;34(5):320-3.
Christidis N, Ghafouri B, Larsson A, Palstam A, Mannerkorpi K, Bileviciute-Ljungar I, et al. Comparison of the levels of pro-inflammatory cytokines released in the vastus lateralis muscle of patients with fibromyalgia and healthy controls during contractions of the quadriceps muscle-a microdialysis study. PLoS One. 2015;10(12):e0143856.
Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, et al. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017;76(2):318-28.
Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38(1):19-28.
Vincent A, Lahr BD, Wolfe F, Clauw DJ, Whipple MO, Oh TH, et al. Prevalence of fibromyalgia: a population-based study in Olmsted County, Minnesota, utilizing the Rochester epidemiology project. Arthritis Care Res (Hoboken). 2013;65(5):786-92.
Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 1990;33(2):160-72.
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, et al. 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-29.
Bjorklund G, Dadar M, Aaseth J. Delayed-type hypersensitivity to metals in connective tissue diseases and fibromyalgia. Environ Res. 2018;161:573-9.
Johansen JD, Aalto-Korte K, Agner T, Andersen KE, Bircher A, Bruze M, et al. European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice. Contact Dermatitis. 2015;73(4):195-221.
Mowitz M, Zimerson E, Svedman C, Bruze M. Stability of fragrance patch test preparations applied in test chambers. Br J Dermatol. 2012;167(4):822-7.
Fregert S. Manual of contact dermatitis. Copenhagen: Munksgaard; 1981.
Diepgen TL, Ofenloch RF, Bruze M, Bertuccio P, Cazzaniga S, Coenraads PJ, et al. Prevalence of contact allergy in the general population in different European regions. Br J Dermatol. 2016;174(2):319-29.
Naldi L, Cazzaniga S, Gonçalo M, Diepgen T, Bruze M, Elsner P, et al. Prevalence of self-reported skin complaints and avoidance of common daily life consumer products in selected European regions. JAMA Dermatol. 2014;150(2):154-63.
Rossi M, Coenraads PJ, Diepgen T, Svensson Å, Elsner P, Gonçalo M, et al. Design and feasibility of an international study assessing the prevalence of contact allergy to fragrances in the general population: the European Dermato-epidemiology network fragrance study. Dermatology. 2010;221(3):267-75.
Bruze M, Mowitz M, Ofenloch R, Coenraads PJ, Diepgen TL, Elsner P, et al. The significance of batch and patch test method in establishing contact allergy to fragrance mix I-EDEN fragrance study group. Contact Dermatitis. 2019;81(2):104-9.
Bruze M, Isaksson M, Gruvberger B, Frick-Engfeldt M. Recommendation of appropriate amounts of petrolatum preparation to be applied at patch testing. Contact Dermatitis. 2007;56(5):281-5.
Marcusson JA, Lindh G, Evengard B. Chronic fatigue syndrome and nickel allergy. Contact Dermatitis. 1999;40(5):269-72.
Stejskal V, Ockert K, Bjorklund G. Metal-induced inflammation triggers fibromyalgia in metal-allergic patients. Neuro Endocrinol Lett. 2013;34(6):559-65.
Stejskal V. Metals as a common trigger of inflammation resulting in non-specific symptoms: diagnosis and treatment. Isr Med Assoc J. 2014;16(12):753-8.
Guccione J, Jacob SE. Metal hypersensitivity in the context of connective tissue disease - an opportunity for practice prevention. Environ Res. 2018;165:322-3.
Miller CS. The compelling anomaly of chemical intolerance. Ann N Y Acad Sci. 2001;933:1-23.
Svedman C, Ekqvist S, Möller H, Björk J, Gruvberger B, Holmström E, et al. Unexpected sensitization routes and general frequency of contact allergies in an elderly stented Swedish population. Contact Dermatitis. 2007;56(6):338-43.
Sukakul T, Bruze M, Mowitz M, Antelmi A, Bergendorff O, Björk J, et al. Contact allergy to oxidized linalool and oxidized limonene: patch testing in consecutive patients with dermatitis. Contact Dermatitis. 2022;86(1):15-24.
Karshikoff B, Jensen KB, Kosek E, Kalpouzos G, Soop A, Ingvar M, et al. Why sickness hurts: a central mechanism for pain induced by peripheral inflammation. Brain Behav Immun. 2016;57:38-46.