Reduced sarcoplasmic reticulum Ca

Mice Animals Sarcoplasmic Reticulum / metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism Calcium / metabolism Myocytes, Cardiac / metabolism Myocardial Ischemia / complications Myocardial Infarction / metabolism Cardiomyopathies / etiology Anti-Arrhythmia Agents
Arrhythmia Cardiac function Heart failure Myocardial infarction SERCA2a

Journal

Heart rhythm
ISSN: 1556-3871
Titre abrégé: Heart Rhythm
Pays: United States
ID NLM: 101200317

Informations de publication

Date de publication:
12 2022
Historique:
received: 09 05 2022
revised: 26 07 2022
accepted: 16 08 2022
pubmed: 27 8 2022
medline: 6 12 2022
entrez: 26 8 2022
Statut: ppublish

Résumé

We have described an arrhythmic mechanism seen only in cardiomyopathy that involves increased mitochondrial Ca We tested the role of SERCA2a in arrhythmias during ischemic cardiomyopathy. Myocardial infarction (MI) was induced in wild-type (Wt) and SERCA2a heterozygous knockdown (SERCA Compared with Wt MI mice, SERCA2a heterozygous knockdown (SERCA SERCA2a knockdown was antiarrhythmic after MI without affecting overall systolic performance. Possible antiarrhythmic mechanisms included reduced SR free Ca

Sections du résumé

BACKGROUND
We have described an arrhythmic mechanism seen only in cardiomyopathy that involves increased mitochondrial Ca
OBJECTIVE
We tested the role of SERCA2a in arrhythmias during ischemic cardiomyopathy.
METHODS
Myocardial infarction (MI) was induced in wild-type (Wt) and SERCA2a heterozygous knockdown (SERCA
RESULTS
Compared with Wt MI mice, SERCA2a heterozygous knockdown (SERCA
CONCLUSION
SERCA2a knockdown was antiarrhythmic after MI without affecting overall systolic performance. Possible antiarrhythmic mechanisms included reduced SR free Ca

Identifiants

DOI: 10.1016/j.hrthm.2022.08.022 PMID: 36028211
pubmed: 36028211
pii: S1547-5271(22)02317-7
doi: 10.1016/j.hrthm.2022.08.022
pii:
doi:

Substances chimiques

Sarcoplasmic Reticulum Calcium-Transporting ATPases EC 3.6.3.8
Calcium SY7Q814VUP
Anti-Arrhythmia Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2107-2114

Subventions

Organisme : NHLBI NIH HHS
ID : R56 HL162208
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL106592
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104025
Pays : United States

Informations de copyright

Copyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Auteurs

An Xie (A)

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota.

Hong Liu (H)

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota.

Gyeoung-Jin Kang (GJ)

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota.

Feng Feng (F)

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota.

Samuel C Dudley (SC)

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota. Electronic address: sdudley@umn.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Eucaryotes › Animaux › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Réticulum endoplasmique lisse › Réticulum sarcoplasmique › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Calcium-Transporting ATPases › Sarcoplasmic Reticulum Calcium-Transporting ATPases › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Reduced sarcoplasmic reticulum Ca
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antiarythmiques › Reduced sarcoplasmic reticulum Ca