Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group.

Anorexia Nervosa / diagnostic imaging Brain / diagnostic imaging Cerebral Cortex / diagnostic imaging Female Humans Magnetic Resonance Imaging / methods Multicenter Studies as Topic Prospective Studies Thinness
BMI Cortical thickness MRI Subcortical volume Surface area

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
01 11 2022
Historique:
received: 05 11 2021
revised: 01 04 2022
accepted: 28 04 2022
pubmed: 29 8 2022
medline: 12 10 2022
entrez: 28 8 2022
Statut: ppublish

Résumé

The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and dependencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data. We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251). In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of undernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients. The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.

Sections du résumé

BACKGROUND
The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and dependencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data.
METHODS
We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251).
RESULTS
In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of undernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients.
CONCLUSIONS
The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.

Identifiants

DOI: 10.1016/j.biopsych.2022.04.022 PMID: 36031441
pubmed: 36031441
pii: S0006-3223(22)01290-2
doi: 10.1016/j.biopsych.2022.04.022
pii:
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

730-738

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH042984
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH118418
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH093535
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH112949
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096777
Pays : United States
Organisme : NIMH NIH HHS
ID : RC1 MH088678
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH080135
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH105662
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Esther Walton (E)

Department of Psychology, University of Bath, Bath, United Kingdom.

Fabio Bernardoni (F)

Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Victoria-Luise Batury (VL)

Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Klaas Bahnsen (K)

Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Sara Larivière (S)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec.

Giovanni Abbate-Daga (G)

Eating Disorders Center for Treatment and Research, University of Turin, Turin, Italy.

Susana Andres-Perpiña (S)

Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Centro de Investigación Biomédica en Red de Salud Mental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

Lasse Bang (L)

Norwegian Institute of Public Health, Oslo; Regional Department for Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Amanda Bischoff-Grethe (A)

Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.

Samantha J Brooks (SJ)

School of Psychology, Faculty of Health Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Department of Neuroscience, Uppsala University, Sweden.

Iain C Campbell (IC)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Eating Disorders Unit, Department of Psychological Medicine, King's College London, London, United Kingdom.

Giammarco Cascino (G)

Section of Neurosciences, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

Josefina Castro-Fornieles (J)

Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Centro de Investigación Biomédica en Red de Salud Mental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

Enrico Collantoni (E)

Department of Neuroscience, University of Padova, Padova, Italy.

Federico D'Agata (F)

Department of Neuroscience, University of Turin, Turin, Italy.

Brigitte Dahmen (B)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.

Unna N Danner (UN)

Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands; Faculty of Social Sciences, Utrecht University, Utrecht, the Netherlands.

Angela Favaro (A)

Department of Neuroscience, University of Padova, Padova, Italy; Padova Neuroscience Center, University of Padova, Padova, Italy.

Jamie D Feusner (JD)

Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, California.

Guido K W Frank (GKW)

Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.

Hans-Christoph Friederich (HC)

Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.

John L Graner (JL)

Center for Cognitive Neuroscience, Duke University, Durham, North Carolina.

Beate Herpertz-Dahlmann (B)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.

Andreas Hess (A)

Institute for Pharmacology and Toxicology, University Erlangen-Nuremberg, Erlangen, Germany.

Stefanie Horndasch (S)

Department of Child and Adolescent Psychiatry, University Clinic Erlangen, Erlangen, Germany.

Allan S Kaplan (AS)

Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

Lisa-Katrin Kaufmann (LK)

Department of Consultation-Liaison Psychiatry and Psychosomatics, University Hospital Zurich, University of Zurich; Division of Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland.

Walter H Kaye (WH)

Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.

Sahib S Khalsa (SS)

Laureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma.

Kevin S LaBar (KS)

Center for Cognitive Neuroscience, Duke University, Durham, North Carolina.

Luca Lavagnino (L)

Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston Texas.

Luisa Lazaro (L)

Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Centro de Investigación Biomédica en Red de Salud Mental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

Renzo Manara (R)

Department of Neuroscience, University of Padova, Padova, Italy.

Amy E Miles (AE)

Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

Gabriella F Milos (GF)

Department of Consultation-Liaison Psychiatry and Psychosomatics, University Hospital Zurich, University of Zurich.

Alessio Maria Monteleone (AM)

Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.

Palmiero Monteleone (P)

Section of Neurosciences, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

Benson Mwangi (B)

Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston Texas.

Owen O'Daly (O)

Centre for Neuroimaging Studies, King's College London, London, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Jose Pariente (J)

Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Julie Roesch (J)

Department of Neuroradiology, University Clinic Erlangen, Erlangen, Germany.

Ulrike H Schmidt (UH)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Eating Disorders Unit, Department of Psychological Medicine, King's College London, London, United Kingdom.

Jochen Seitz (J)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.

Megan E Shott (ME)

Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.

Joe J Simon (JJ)

Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.

Paul A M Smeets (PAM)

UMC Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands; Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.

Christian K Tamnes (CK)

Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.

Elena Tenconi (E)

Department of Neuroscience, University of Padova, Padova, Italy; Padova Neuroscience Center, University of Padova, Padova, Italy.

Sophia I Thomopoulos (SI)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California.

Annemarie A van Elburg (AA)

Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands; Faculty of Social Sciences, Utrecht University, Utrecht, the Netherlands.

Aristotle N Voineskos (AN)

Campbell Family Mental Health Research Institute, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Georg G von Polier (GG)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany; Institute for Neuroscience and Medicine: Brain and Behaviour, Forschungszentrum Jülich, Jülich, Germany; Department of Child and Adolescent Psychiatry, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.

Christina E Wierenga (CE)

Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.

Nancy L Zucker (NL)

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina.

Neda Jahanshad (N)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California.

Joseph A King (JA)

Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Paul M Thompson (PM)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California.

Laura A Berner (LA)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Stefan Ehrlich (S)

Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. Electronic address: transden.lab@uniklinikum-dresden.de.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Anorexie mentale › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études multicentriques comme sujet › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Brain Structure in Acutely Underweight and...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Maigreur › Brain Structure in Acutely Underweight and...