Hyperoxemia is Associated With Poor Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry.
extracorporeal cardiopulmonary resuscitation
hyperoxemia
neurological outcome
out-of-hospital cardiac arrest
Journal
The Journal of emergency medicine
ISSN: 0736-4679
Titre abrégé: J Emerg Med
Pays: United States
ID NLM: 8412174
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
28
12
2021
revised:
05
04
2022
accepted:
09
05
2022
pubmed:
30
8
2022
medline:
21
9
2022
entrez:
29
8
2022
Statut:
ppublish
Résumé
Previous studies have shown an association between hyperoxemia and mortality in patients with out-of-hospital cardiac arrest (OHCA) after cardiopulmonary resuscitation (CPR); however, evidence is lacking in the extracorporeal CPR (ECPR) setting. The aim of this study was to test the hypothesis that hyperoxemia is associated with poor neurological outcomes in patients treated by ECPR. The Japanese Association for Acute Medicine OHCA Registry is a multicenter, prospective, observational registry of patients from 2014 to 2017. Adult (18 years or older) patients who had undergone ECPR after OHCA were included. Eligible patients were divided into two groups based on the partial pressure of oxygen in arterial blood (PaO Of 34,754 patients with OHCA, 453 patients were included. The neurological outcome was significantly lower in the high-PaO Hyperoxemia was associated with worse neurological outcomes in OHCA patients with ECPR.
Sections du résumé
BACKGROUND
Previous studies have shown an association between hyperoxemia and mortality in patients with out-of-hospital cardiac arrest (OHCA) after cardiopulmonary resuscitation (CPR); however, evidence is lacking in the extracorporeal CPR (ECPR) setting.
OBJECTIVE
The aim of this study was to test the hypothesis that hyperoxemia is associated with poor neurological outcomes in patients treated by ECPR.
METHODS
The Japanese Association for Acute Medicine OHCA Registry is a multicenter, prospective, observational registry of patients from 2014 to 2017. Adult (18 years or older) patients who had undergone ECPR after OHCA were included. Eligible patients were divided into two groups based on the partial pressure of oxygen in arterial blood (PaO
RESULTS
Of 34,754 patients with OHCA, 453 patients were included. The neurological outcome was significantly lower in the high-PaO
CONCLUSIONS
Hyperoxemia was associated with worse neurological outcomes in OHCA patients with ECPR.
Identifiants
pubmed: 36038433
pii: S0736-4679(22)00323-7
doi: 10.1016/j.jemermed.2022.05.018
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-231Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.