Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 08 2022
29 08 2022
Historique:
received:
19
09
2021
accepted:
10
08
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
1
9
2022
Statut:
epublish
Résumé
African trypanosomes are extracellular pathogens of mammals and are exposed to the adaptive and innate immune systems. Trypanosomes evade the adaptive immune response through antigenic variation, but little is known about how they interact with components of the innate immune response, including complement. Here we demonstrate that an invariant surface glycoprotein, ISG65, is a receptor for complement component 3 (C3). We show how ISG65 binds to the thioester domain of C3b. We also show that C3 contributes to control of trypanosomes during early infection in a mouse model and provide evidence that ISG65 is involved in reducing trypanosome susceptibility to C3-mediated clearance. Deposition of C3b on pathogen surfaces, such as trypanosomes, is a central point in activation of the complement system. In ISG65, trypanosomes have evolved a C3 receptor which diminishes the downstream effects of C3 deposition on the control of infection.
Identifiants
pubmed: 36038546
doi: 10.1038/s41467-022-32728-9
pii: 10.1038/s41467-022-32728-9
pmc: PMC9424271
doi:
Substances chimiques
Complement C3
0
Macrophage-1 Antigen
0
Membrane Glycoproteins
0
Protozoan Proteins
0
ISG65 protein, Trypanosoma brucei
147338-68-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5085Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 101020/Z/13/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P001424/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 217138/Z/19/Z
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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